Table 2 Breast cancer ER/PR staining percentage based on germline PV status
Germline PV | Case no. (N) | ER% | PR% | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | p value | CV | CV p value | Mean | SD | p value | CV | CV p value | ||
BRCA1 | 57 | 15.2 | 33.6 | 0.000 | 2.21 | 0.000 | 6.8 | 20.9 | 0.000 | 3.05 | 0.000 |
BRCA2 | 60 | 66.7 | 38.9 | 0.000 | 0.58 | 0.007 | 44.7 | 38.0 | 0.161 | 0.85 | 0.934 |
PALB2 | 22 | 68.2 | 39.5 | 0.111 | 0.58 | 0.087 | 39.5 | 34.4 | 0.156 | 0.87 | 0.867 |
ATM | 22 | 83.2 | 29.2 | 0.540 | 0.35 | 0.306 | 55.8 | 39.3 | 0.344 | 0.70 | 0.539 |
TP53 | 21 | 50.6 | 47.5 | 0.015 | 0.94 | 0.000 | 40.6 | 45.0 | 0.397 | 1.11 | 0.235 |
CHEK2 | 39 | 93.1 | 17.8 | 0.005 | 0.19 | 0.000 | 71.7 | 35.4 | 0.001 | 0.49 | 0.019 |
MMR | 19 | 60.9 | 47.7 | 0.281 | 0.78 | 0.000 | 40.4 | 42.5 | 0.445 | 1.05 | 0.324 |
PTEN | 6 | 98.0 | 3.82 | NC | NC | NC | 87.0 | 17.85 | NC | NC | NC |
CDH1 | 3 | 80.0 | 52.9 | NC | NC | NC | 70.0 | 40.4 | NC | NC | NC |
Control/reference | 78.2 | 34.4 | 0.44 | 41.1 | 0.84 | ||||||