Fig. 6
From: Gene expression predicts dormant metastatic breast cancer cell phenotype
Modulation of dormancy-related genes does not impact the in vivo dormancy phenotype. a qRT-PCR analysis of ectopically expressed dormancy genes in PyMT-Bo1 cells (n = 3). b Whole body BLI tracking of in vivo proliferation of control versus PyMT-Bo1 cells ectopically expressing the genes as indicated, 5 mice per group. c Dormancy gene expression in D2.0R cells after CRISPR/Cas9 knockout determined by qRT-PCR, compared to Cas9 expressing D2.0R cells without a gRNA, which was set to 1 (n = 3). d Representative BLI images tracking the growth of different dormancy gene-KO D2.0R cells in the lung for 30 days, 3 mice per group