Fig. 6

Aberrant KRT13 expression in breast cancer progression and metastasis. Representative results are shown. A metastatic breast cancer (N = 21) expressed higher KRT13 than the primary tumor as determined by IHC staining (N = 41). B mQDL staining scores. C KRT13 expression in primary breast cancer is associated with decreased patient overall survival (Oncomine gene expression datasets). D higher levels of KRT13 are expressed at the invasive front in 5/13 primary breast cancer tumors (Arrows). E, F the relationship of KRT13 and c-Myc expression as suggested by Oncomine analyses. G the relationship of KRT13 and c-Myc level in 62 clinical breast tumor specimens as determined by mQDL. H representative mQDL analysis suggested that high KRT13 expression in clinical breast tumor metastasis was associated with elevated c-Myc and lowered PG expression