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Fig. 3 | Breast Cancer Research

Fig. 3

From: KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway

Fig. 3

KRT13 overexpression promoted EMT and stemness of breast cancer cells. A KRT13 overexpression induced EMT in MCF7 cells as determined by GSEA. B KRT13 overexpression induced stemness-related gene expression as determined by GSEA. C KRT13 immunostain revealed morphologic changes in MCF7-KRT13 cells (400 ×). D altered expression of EMT-associated proteins as determined by western blotting. E altered expression of stemness-related proteins. F number and size changes in mammosphere formation (*p ≤ 0.05 and **p ≤ 0.01). G gain of CD44+/CD24− stem cell phenotype in MCF7-KRT13 cells as detected by flow cytometry. H reduced CD44+/CD24− stem cell marker expression in HCC1954-shKRT13 cells

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Breast Cancer Research

ISSN: 1465-542X

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