| |
Geometric mean (95% CI)
|
p-trend
|
%Δ
|
p-diff
|
|---|
|
Slight
|
Average
|
Slightly heavy
|
Heavy
|
|---|
|
N
|
64
|
189
|
175
|
87
| | | |
|
Median BMI (kg/m2)
|
22
|
25
|
29
|
31
| | | |
|
Estrone
|
277.88 (168.63–457.91)
|
472.03 (299.00–745.19)
|
562.73 (351.76–900.24)
|
748.98 (449.60–1,247.71)
|
< 0.0001
|
58.7
|
< 0.0001
|
|
Unconjugated
|
52.63 (40.17–68.96)
|
66.56 (52.15–84.95)
|
74.68 (57.90–96.31)
|
94.03 (70.48–125.45)
|
< 0.0001
|
41.3
|
< 0.0001
|
|
Conjugated
|
189.16 (105.62–338.78)
|
397.12 (241.72–652.42)
|
474.59 (284.04–792.96)
|
637.85 (365.42–1,113.38)
|
< 0.0001
|
60.6
|
< 0.0001
|
|
Estradiol
|
28.47 (18.21–44.53)
|
41.16 (27.80–60.95)
|
49.45 (32.77–74.60)
|
66.41 (42.42–103.95)
|
< 0.0001
|
61.3
|
< 0.0001
|
|
Unconjugated
|
19.55 (13.51–28.28)
|
30.52 (22.13–42.09)
|
33.98 (24.18–47.74)
|
47.33 (31.93–70.18)
|
< 0.0001
|
55.1
|
< 0.0001
|
|
Conjugated
|
3.86 (1.59–9.38)
|
6.37 (2.83–14.32)
|
10.37 (4.54–23.68)
|
10.18 (4.16–24.94)
|
0.0001
|
59.8
|
0.0011
|
|
2-Hydroxyestrone
|
52.77 (45.52–61.18)
|
62.25 (55.20–70.19)
|
66.33 (57.88–76.03)
|
70.17 (58.93–83.57)
|
0.0008
|
12.7
|
0.0005
|
|
2-Hydroxyestradiol
|
12.07 (8.09–18.01)
|
10.33 (7.24–14.74)
|
10.47 (7.25–15.12)
|
10.17 (6.93–14.92)
|
0.30
|
− 1.6
|
0.18
|
|
2-Methoxyestrone
|
17.04 (13.44–21.59)
|
18.17 (14.85–22.23)
|
18.99 (15.31–23.57)
|
21.42 (16.80–27.31)
|
0.02
|
17.9
|
0.02
|
|
Unconjugated
|
6.21 (4.89–7.89)
|
6.58 (5.44–7.96)
|
6.38 (5.18–7.87)
|
6.79 (5.30–8.70)
|
0.62
|
3.1
|
0.44
|
|
Conjugated
|
8.59 (5.85–12.62)
|
10.03 (7.58–13.27)
|
11.61 (8.57–15.73)
|
14.57 (10.30–20.61)
|
0.001
|
45.3
|
0.003
|
|
2-Methoxyestradiol
|
9.77 (7.65–12.49)
|
10.17 (8.26–12.51)
|
10.40 (8.36–12.94)
|
9.52 (7.50–12.08)
|
0.83
|
− 6.4
|
0.79
|
|
Unconjugated
|
2.63 (2.09–3.32)
|
2.86 (2.38–3.45)
|
2.88 (2.36–3.52)
|
2.84 (2.29–3.52)
|
0.49
|
− 0.7
|
0.40
|
|
Conjugated
|
6.59 (4.56–9.54)
|
6.96 (5.23–9.27)
|
6.78 (4.98–9.22)
|
6.42 (4.59–8.97)
|
0.72
|
− 7.8
|
0.87
|
|
2-Hydroxyestrone-3-methyl ether
|
3.00 (2.32–3.89)
|
3.12 (2.45–3.96)
|
3.29 (2.56–4.24)
|
3.37 (2.56–4.44)
|
0.19
|
8.2
|
0.27
|
|
4-Hydroxyestrone
|
6.60 (4.51–9.65)
|
7.60 (5.46–10.58)
|
8.46 (5.96–12.00)
|
9.47 (6.58–13.63)
|
0.0007
|
24.6
|
0.002
|
|
4-Methoxyestrone
|
3.07 (2.52–3.74)
|
3.00 (2.58–3.48)
|
3.19 (2.72–3.76)
|
3.08 (2.55–3.71)
|
0.63
|
2.6
|
0.98
|
|
4-Methoxyestradiol
|
1.51 (1.16–1.95)
|
1.58 (1.29–1.92)
|
1.61 (1.29–2.00)
|
1.63 (1.30–2.05)
|
0.42
|
3.3
|
0.44
|
|
16α-Hydroxyestrone
|
21.42 (14.99–30.61)
|
30.66 (22.61–41.57)
|
29.25 (21.00–40.73)
|
37.29 (25.86–53.75)
|
0.002
|
21.6
|
0.0001
|
|
Estriol
|
85.14 (69.73–103.95)
|
92.92 (79.22–109.00)
|
95.18 (79.99–113.26)
|
113.48 (90.92–141.64)
|
0.014
|
22.1
|
0.01
|
|
Unconjugated
|
9.53 (8.17–11.13)
|
9.74 (8.64–10.98)
|
10.44 (9.09–11.99)
|
9.86 (8.50–11.44)
|
0.28
|
1.3
|
0.61
|
|
Conjugated
|
73.92 (59.01–92.59)
|
80.71 (67.41–96.64)
|
81.25 (66.65–99.06)
|
102.40 (80.16–130.81)
|
0.017
|
26.9
|
0.01
|
|
16-Ketoestradiol
|
11.97 (9.51–15.07)
|
15.74 (13.33–18.57)
|
15.69 (12.99–18.95)
|
19.92 (15.74–25.21)
|
0.0002
|
26.6
|
< 0.0001
|
|
16-Epiestriol
|
16.64 (12.80–21.63)
|
19.37 (15.52–24.17)
|
19.88 (15.86–24.92)
|
22.85 (17.56–29.74)
|
0.008
|
18.0
|
0.005
|
|
17-Epiestriol
|
19.86 (13.54–29.15)
|
20.60 (14.42–29.42)
|
20.95 (14.54–30.19)
|
20.68 (14.15–30.22)
|
0.70
|
0.4
|
0.71
|
- Geometric means adjusted for age at blood draw (continuous), blood draw year (2013, 2014, 2015), smoking status (never, former, current, missing), diabetes (yes, no, missing), time since menopause (≤ 2, 3–5, 6–10, > 10, missing), ever used oral contraceptives (yes, no, missing)
- p-trend was estimated using the Wald test for ordinal body size category
- %Δ indicates the percentage change in estrogen/estrogen metabolite levels, comparing women with heavy body size category to average sized women, and was estimated by taking the ratio of the geometric mean difference in estrogen/estrogen metabolite levels between women reporting heavy body size categories minus average body size category to the geometric mean of women with average body size, multiplied by 100 (we could do this in the table to slight)
- p-diff was estimated using the Wald test and indicates a p-value for comparing estrogen/estrogen metabolite levels of women with current heavy body size vs. average body size
- Bold p-values represent FDR ≤ 0.05
