| Geometric mean (95% CI) | p-trend | %Δ | p-diff | |||
---|---|---|---|---|---|---|---|
Underweight (< 18.5 kg/m2) | Healthy weight (18.5–24.9 kg/m2) | Overweight (25.0–29.9 kg/m2) | Obese (30 + kg/m2) | ||||
N | 20 | 193 | 169 | 154 | Â | Â | Â |
Median BMI (kg/m2) | 18 | 22 | 27 | 34 | Â | Â | Â |
Estrone | 144.97 (88.25–238.13) | 224.99 (170.21–297.39) | 318.61 (239.30–424.21) | 448.63 (336.80–597.58) |  < 0.0001 | 99.4 |  < 0.0001 |
 Unconjugated | 41.70 (32.20–54.00) | 50.89 (43.47–59.59) | 64.64 (54.90–76.12) | 78.90 (66.57–93.53) |  < 0.0001 | 55.0 |  < 0.0001 |
 Conjugated | 93.85 (50.12–175.77) | 165.03 (117.93–230.94) | 251.15 (178.34–353.68) | 366.55 (260.70–515.40) |  < 0.0001 | 122.1 |  < 0.0001 |
Estradiol | 16.77 (10.73–26.23) | 19.68 (14.73–26.31) | 29.63 (21.93–40.02) | 41.81 (31.07–56.27) |  < 0.0001 | 112.4 |  < 0.0001 |
 Unconjugated | 11.50 (8.05–16.42) | 13.26 (10.37–16.95) | 19.80 (15.25–25.71) | 27.83 (21.47–36.07) |  < 0.0001 | 109.9 |  < 0.0001 |
 Conjugated | 2.24 (0.83–6.03) | 3.32 (1.65–6.67) | 5.02 (2.50–10.08) | 7.32 (3.67–14.59) |  < 0.0001 | 120.4 |  < 0.0001 |
2-Hydroxyestrone | 45.44 (37.43–55.16) | 51.36 (45.24–58.31) | 53.48 (46.66–61.30) | 58.42 (51.15–66.73) | 0.01 | 13.7 | 0.03 |
2-Hydroxyestradiol | 12.35 (8.23–18.53) | 9.38 (7.04–12.51) | 8.39 (6.22–11.31) | 8.50 (6.37–11.36) | 0.06 | − 9.4 | 0.24 |
2-Methoxyestrone | 19.75 (14.41–27.06) | 21.17 (17.44–25.70) | 21.43 (17.55–26.17) | 23.20 (18.91–28.46) | 0.15 | 9.6 | 0.20 |
 Unconjugated | 8.54 (5.90–12.36) | 8.56 (6.84–10.71) | 9.07 (7.22–11.40) | 8.42 (6.68–10.62) | 0.93 | − 1.6 | 0.84 |
 Conjugated | 8.67 (5.29–14.21) | 9.57 (7.26–12.60) | 9.94 (7.58–13.02) | 12.75 (9.61–16.92) | 0.02 | 33.3 | 0.02 |
2-Methoxyestradiol | 10.55 (7.23–15.38) | 12.92 (10.00–16.68) | 12.82 (10.01–16.42) | 13.17 (10.18–17.03) | 0.44 | 1.9 | 0.78 |
 Unconjugated | 2.88 (2.02–4.11) | 2.86 (2.27–3.60) | 2.89 (2.27–3.68) | 2.94 (2.32–3.73) | 0.65 | 3.0 | 0.62 |
 Conjugated | 6.39 (3.61–11.29) | 9.09 (6.33–13.04) | 8.36 (5.88–11.89) | 8.89 (6.22–12.70) | 0.76 | − 2.2 | 0.83 |
2-Hydroxyestrone-3-methyl ether | 3.52 (2.56–4.83) | 3.68 (2.97–4.58) | 3.69 (2.96–4.60) | 3.79 (3.06–4.71) | 0.61 | 3.0 | 0.69 |
4-Hydroxyestrone | 6.29 (4.35–9.09) | 6.62 (4.76–9.21) | 7.13 (5.16–9.84) | 8.36 (6.06–11.52) | 0.004 | 26.3 | 0.007 |
4-Methoxyestrone | 3.95 (2.96–5.27) | 3.58 (2.87–4.46) | 3.62 (2.89–4.54) | 3.60 (2.89–4.47) | 0.85 | 0.5 | 0.94 |
4-Methoxyestradiol | 1.48 (1.04–2.11) | 1.54 (1.24–1.92) | 1.45 (1.18–1.78) | 1.58 (1.28–1.97) | 0.73 | 2.6 | 0.71 |
16α-Hydroxyestrone | 23.04 (14.78–35.90) | 29.08 (20.92–40.42) | 37.98 (27.19–53.04) | 50.14 (36.11–69.62) |  < 0.0001 | 72.4 |  < 0.0001 |
Estriol | 82.19 (58.33–115.80) | 82.48 (65.95–103.16) | 95.37 (75.16–121.02) | 105.42 (83.45–133.17) | 0.001 | 27.8 | 0.002 |
 Unconjugated | 9.28 (7.62–11.29) | 9.43 (8.38–10.62) | 10.05 (8.97–11.27) | 9.21 (8.21–10.33) | 0.78 | − 2.4 | 0.56 |
 Conjugated | 70.77 (47.79–104.79) | 70.06 (54.67–89.77) | 82.52 (63.50–107.24) | 94.71 (73.17–122.60) | 0.0006 | 35.2 | 0.0007 |
16-Ketoestradiol | 11.97 (8.87–16.16) | 17.24 (13.76–21.59) | 19.72 (15.58–24.97) | 27.89 (22.13–35.14) |  < 0.0001 | 61.8 |  < 0.0001 |
16-Epiestriol | 17.41 (11.22–27.02) | 16.63 (13.07–21.16) | 18.96 (14.91–24.09) | 20.47 (16.06–26.08) | 0.011 | 23.0 | 0.008 |
17-Epiestriol | 28.50 (19.39–41.90) | 25.07 (18.83–33.38) | 26.02 (19.77–34.26) | 27.13 (20.51–35.88) | 0.44 | 8.2 | 0.27 |