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Table 3 Hazard ratios (HRs) and 95% confidence intervals (CI) for breast cancer specific and overall mortality per THRα-2 expression

From: Low thyroid hormone receptor alpha-2 (THRα-2) tumor expression is associated with unfavorable tumor characteristics and high breast cancer mortality

Endpoint

THRα-2

All

(n)

Deaths

(n)

HRcrude

(95% CI)

HRa

(95% CI)

HRb

(95% CI)

HRCC

(95% CI)

Breast cancer specific mortality

Low

309

67

1.38 (0.96–1.99)

1.48 (1.03–2.14)

0.98 (0.66–1.45)

0.81 (0.52–1.26)

All of follow-up

High

345

52

1

1

1

1

 

Total

654

119

    

Breast cancer specific mortality

Low

309

61

1.52 (1.03–2.24)

1.64 (1.11–2.43)

1.04 (0.68–1.58)

0.86 (0.54–1.39)

0–15 years of follow-up

High

345

44

1

1

1

1

 

Total

654

105

    

Overall mortality

Low

309

127

1.04 (0.82–1.34)

1.22 (0.95–1.56)

0.94 (0.72–1.23)

0.89 (0.65–1.21)

All of follow-up

High

345

127

1

1

1

1

 

Total

654

254

    

Overall mortality

Low

309

110

1.16 (0.82–1.34)

1.36 (1.04–1.79)

1.00 (0.75–1.34)

0.94 (0.68–1.32)

0–15 years of follow-up

High

345

102

1

1

1

1

 

Total

654

212

    
  1. aAdjusted for: age at diagnosis
  2. bAdjusted for: age at diagnosis, tumor size, axillary lymph node involvement and surrogate intrinsic subtype
  3. CCComplete case analysis, adjusted for same as b