Table 2 Tumor characteristics and THRα-2 expression
THRα-2 fraction | THRα-2 intensity | Combined* | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
< 1% | 1–10% | 11–50% | 51–75% | 76–100% | No staining | Weak | Moderate | Strong | Low | High | OR (95% CI) | |
Surrogate | ||||||||||||
Luminal A-like | 21.2 | 30.1 | 40.1 | 46.6 | 65.1 | 21.2 | 44.3 | 62.4 | 69.1 | 43.7 | 66.0 | 1 |
Intrinsic subtypes | ||||||||||||
Luminal B-like | 35.3 | 35.2 | 30.5 | 29.0 | 21.7 | 35.3 | 27.8 | 23.1 | 23.8 | 29.0 | 22.0 | 1.99 (1.34–2.97) |
HER2+ | 20.0 | 13.7 | 12.2 | 10.7 | 7.9 | 20.0 | 11.0 | 10.7 | 1.2 | 12.0 | 7.5 | 2.42 (1.38–4.27) |
Triple-negative | 23.6 | 20.9 | 17.3 | 13.6 | 5.2 | 23.6 | 16.9 | 3.9 | 5.9 | 15.3 | 4.5 | 5.10 (2.70–9.65) |
ER | ||||||||||||
> 10% | 65.5 | 71.6 | 80.5 | 85.1 | 93.1 | 65.5 | 79.3 | 94.9 | 94.1 | 81.0 | 94.5 | 1 |
≤ 10% | 34.5 | 28.4 | 19.5 | 14.9 | 6.9 | 34.5 | 20.7 | 5.1 | 5.9 | 19.0 | 5.5 | 4.04 (2.28–7.15) |
PgR | ||||||||||||
> 10% | 6.8 | 24.4 | 28.6 | 54.5 | 69.4 | 6.8 | 29.8 | 70.3 | 96.2 | 35.8 | 76.3 | 1 |
≤ 10% | 93.2 | 75.6 | 71.4 | 45.5 | 30.6 | 93.2 | 70.2 | 29.7 | 3.8 | 64.2 | 23.7 | 5.77 (4.00–8.33) |
HER2 | ||||||||||||
Negative | 80.1 | 86.3 | 87.9 | 89.3 | 92.1 | 80.1 | 89.0 | 89.4 | 98.8 | 88.1 | 92.6 | 1 |
Positive | 19.9 | 13.7 | 12.1 | 10.7 | 7.9 | 19.9 | 11.0 | 10.6 | 1.2 | 11.9 | 7.4 | 1.69 (0.98–2.92) |
Ki67** | ||||||||||||
Low | 24.5 | 31.1 | 36.5 | 34.1 | 44.8 | 24.5 | 40.7 | 43.4 | 34.5 | 38.8 | 42.2 | 1 |
Intermediate | 39.2 | 30.2 | 30.1 | 32.9 | 31.1 | 39.2 | 27.1 | 31.0 | 42.0 | 29.5 | 33.0 | 0.97 (0.65–1.47) |
High | 36.3 | 38.7 | 33.5 | 33.0 | 24.1 | 36.3 | 32.2 | 25.6 | 23.5 | 31.7 | 24.8 | 1.46 (1.00–2.12) |
Grade** | ||||||||||||
Grade I | 12.5 | 7.5 | 17.5 | 16.7 | 30.2 | 12.5 | 17.1 | 32.7 | 20.6 | 17.7 | 30.4 | 1 |
Grade II | 31.3 | 40.0 | 45.1 | 45.4 | 50.9 | 31.3 | 46.6 | 45.2 | 63.0 | 45.2 | 50.6 | 1.53 (1.03–2.29) |
Grade III | 56.3 | 52.5 | 37.4 | 38.0 | 18.9 | 56.3 | 36.3 | 22.2 | 16.4 | 37.0 | 19.0 | 3.34 (2.13–5.24) |
Tumor size (mm)** | ||||||||||||
≤ 10 | 12.5 | 15.0 | 10.2 | 16.7 | 23.6 | 12.5 | 18.0 | 20.8 | 22.7 | 16.8 | 22.5 | 1 |
11–20 | 12.5 | 47.5 | 47.7 | 49.1 | 50.4 | 12.5 | 46.0 | 52.1 | 51.5 | 43.7 | 53.2 | 1.10 (0.73–1.67) |
21–50 | 75.0 | 30.0 | 39.8 | 31.5 | 22.8 | 75.0 | 32.0 | 23.9 | 23.7 | 35.6 | 21.6 | 2.20 (1.39–3.49) |
> 50 | 0.0 | 7.5 | 2.3 | 2.8 | 3.3 | 0.0 | 4.0 | 3.1 | 2.1 | 3.9 | 2.6 | 1.98 (0.78–5.02) |
ALNI | ||||||||||||
No | 31.3 | 60.0 | 63.5 | 58.7 | 70.1 | 31.3 | 63.8 | 68.3 | 69.1 | 60.6 | 70.4 | 1 |
Yes | 68.8 | 40.0 | 36.5 | 41.3 | 29.9 | 68.8 | 36.2 | 31.7 | 30.9 | 39.4 | 29.6 | 1.55 (1.11–2.15) |