Fig. 6

Postn gene expression is regulated by both bFGF and TGFβ. Schematic summarizing the regulation of Postn by TGFβ and FGF2. PI3K/AKT is the main drive of Postn expression. Although the exact effectors remain to be identified, FGFR signaling can repress Postn expression by acting on the PI3K/AKT pathway at one or multiple levels. TGFβ signaling is shown to activate PI3K to promote AKT activation and the expression of Postn. Other growth factor receptors and surface integrins shown to activate Postn through AKT are also represented