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Table 1 Distribution of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and grade and the intrinsic-like subtypes for cases of invasive breast cancer in studies from the Breast Cancer Consortium Association

From: Common variants in breast cancer risk loci predispose to distinct tumor subtypes

Tumor marker

N (%)

ER

 Negative

16,900 (19%)

 Positive

70,030 (81%)

 Unknown

19,641

PR

 Negative

24,283 (32%)

 Positive

51,603 (68%)

 Unknown

30,685

HER2

 Negative

47,693 (83%)

 Positive

9,529 (17%)

 Unknown

49,349

Grade

 1

15,583 (20%)

 2

37,568 (49%)

 3

24,382 (31%)

 Unknown

29,038

Intrinsic-like subtypes

 Luminal A-like

27,510 (54%)

 Luminal B-like/HER2-negative

6,804 (13%)

 Luminal B-like/HER2-positive

6,511 (13%)

 HER2-positive/non-luminal

2,797 (6%)

 Triple-negative

7,178 (14%)

 Unknown

55,771

  1. Luminal A-like (ER + and/or PR + , HER2-, grade 1 & 2); Luminal B-like/HER2-negative (ER + and/or PR + , HER2-, grade 3); Luminal B-like/HER2-positive (ER + and/or PR + , HER2 +); HER2-positive/non-luminal (ER- and PR-, HER2 +), and triple-negative (ER-, PR-, HER2-)