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Table 4 Association between neighborhood-level factors and risk of ER− breast cancer stratified by years of education

From: Neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women

Exposure

 ≤ 12 years of education

 > 12 years of education

Cases

Person-years

Age-adjusted HR (95% CI)a

MV-adjusted HR (95% CI)b

Cases

Person-years

Age-adjusted HR (95% CI)a

MV-adjusted HR (95% CI)b

Neighborhood SESc

 Quartile 1 (low)

51

75,846

1.32 (0.86–2.03)

1.48 (0.95–2.31)

112

182,610

1.09 (0.88–1.37)

1.12 (0.89–1.40)

 Quartile 2

36

52,647

1.31 (0.82–2.09)

1.39 (0.87–2.22)

123

205,192

1.08 (0.87–1.33)

1.09 (0.88–1.36)

 Quartiles 3 and 4 (higher)

35

65,509

1.00 (ref)

1.00 (ref)

267

476,572

1.00 (ref)

1.00 (ref)

Neighborhood concentrated disadvantaged

 Quartiles 1 and 2 (lower)

36

72,687

1.00 (ref)

1.00 (ref)

267

469,971

1.00 (ref)

1.00 (ref)

 Quartile 3

30

53,516

1.15 (0.71–1.86)

1.23 (0.75–2.00)

135

217,510

1.08 (0.88–1.33)

1.09 (0.88–1.34)

 Quartile 4 (high)

59

72,780

1.67 (1.10–2.53)

1.94 (1.26–2.99)

111

189,808

1.01 (0.81–1.26)

1.02 (0.81–1.28)

  1. ER estrogen receptor, HR hazard ratio, CI confidence interval, MV multivariable, SES socioeconomic status
  2. aHazard ratios adjusted for age and time period
  3. bHazard ratios additionally adjusted for age at menarche, BMI at age 18, parity, age at first birth, breastfeeding, menopausal status, age at menopause, oral contraceptive use for 5 + years, family history of breast cancer, geographic region and physical activity
  4. cPinteraction = 0.91
  5. dPinteraction = 0.15