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Table 3 Association between neighborhood-level factors and risk of breast cancer by ER status and for triple negative breast cancer

From: Neighborhood disadvantage and individual-level life stressors in relation to breast cancer incidence in US Black women

Exposure

ER+

ER−

Triple negative

Cases

Age-adjusted HR (95% CI)a

MV-adjusted HR (95% CI)b

Cases

Age-adjusted HR (95% CI)a

MV-adjusted HR (95% CI)b

Cases

Age-adjusted HR (95% CI)a

MV-adjusted HR (95% CI)b

Neighborhood SES

 Quartile 1 (low)

245

0.73 (0.62–0.86)

0.83 (0.70–0.98)

163

1.17 (0.94–1.47)

1.24 (0.98–1.57)

65

1.29 (0.91–1.84)

1.29 (0.91–1.84)

 Quartile 2

282

0.86 (0.73–1.01)

0.93 (0.79–1.10)

159

1.16 (0.92–1.45)

1.20 (0.96–1.51)

68

1.20 (0.85–1.71)

1.20 (0.85–1.71)

 Quartile 3

300

0.87 (0.74–1.02)

0.91 (0.78–1.06)

159

1.10 (0.88–1.38)

1.12 (0.89–1.40)

81

1.14 (0.81–1.60)

1.14 (0.81–1.60)

 Quartile 4 (high)

336

1.00 (ref)

1.00 (ref)

143

1.00 (ref)

1.00 (ref)

75

1.00 (ref)

1.00 (ref)

 P-trend

 

0.0003

0.05

 

0.14

0.06

 

0.46

0.15

Neighborhood concentrated disadvantage

 Quartile 1 (low)

303

1.00 (ref)

1.00 (ref)

142

1.00 (ref)

1.00 (ref)

71

1.00 (ref)

1.00 (ref)

 Quartile 2

306

0.98 (0.84–1.15)

1.02 (0.87–1.19)

161

1.11 (0.89–1.40)

1.14 (0.91–1.43)

69

1.01 (0.72–1.42)

1.04 (0.74–1.46)

 Quartile 3

315

0.99 (0.85–1.16)

1.05 (0.89–1.23)

165

1.14 (0.91–1.43)

1.18 (0.94–1.48)

72

1.19 (0.86–1.65)

1.25 (0.90–1.74)

 Quartile 4 (high)

261

0.83 (0.70–0.97)

0.92 (0.77–1.09)

170

1.19 (0.95–1.49)

1.26 (1.00–1.58)

63

1.13 (0.81–1.58)

1.25 (0.88–1.76)

 P-trend

 

0.03

0.47

 

0.13

0.06

 

0.32

0.13

Neighborhood SES and concentrated disadvantage combination

 Highest SES, least disadvantaged

379

1.00 (ref)

1.00 (ref)

176

1.00 (ref)

1.00 (ref)

79

1.00 (ref)

1.00 (ref)

 Intermediate SES/disadvantage

508

0.97 (0.85–1.11)

1.03 (0.90–1.17)

266

1.11 (0.92–1.35)

1.14 (0.94–1.38)

122

1.12 (0.84–1.49)

1.16 (0.87–1.54)

 Lowest SES, most disadvantaged

304

0.80 (0.69–0.93)

0.90 (0.77–1.05)

199

1.17 (0.96–1.44)

1.23 (1.00–1.52)

89

1.14 (0.84–1.55)

1.25 (0.91–1.72)

 P-trend

 

0.005

0.21

 

0.12

0.05

 

0.39

0.16

  1. ER estrogen receptor, HR hazard ratio, CI confidence interval, MV multivariable, SES socioeconomic status
  2. aHazard ratios adjusted for age and time period
  3. bHazard Ratios additionally adjusted for age at menarche, BMI at age 18, parity, age at first birth, breastfeeding, menopausal status, age at menopause, oral contraceptive use for 5 + years, family history of breast cancer, geographic region and physical activity
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Breast Cancer Research

ISSN: 1465-542X

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