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Fig. 4 | Breast Cancer Research

Fig. 4

From: STAT5 is activated in macrophages by breast cancer cell-derived factors and regulates macrophage function in the tumor microenvironment

Fig. 4

STAT5 in macrophages differentially regulates expression of adaptive immunity-related and tumor-promoting genes. A Heatmap of differentially regulated genes comparing STAT5fl/fl or STAT5cKO macrophages treated with No CM, recombinant GM-CSF (rmGM-CSF), or 4T1 CM. B Gene ontology analysis showing pathways altered based on genes that are downregulated in STAT5cKO macrophages stimulated with rmGM-CSF (left panel) and 4T1 CM (right panel). C, D Gene ontology analysis showing biological processes downregulated and upregulated in 4T1 CM-treated STAT5cKO BMDMs, respectively. E Positively enriched (red) and negatively enriched (blue) GSEA pathways in 4T1 CM-treated STAT5cKO BMDMs. F The changes in expression of Epithelial to Mesenchymal Transition (top) and Interferon Gamma Response (bottom) genes in 4T1 CM-treated STAT5cKO BMDMs analyzed by GSEA

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Breast Cancer Research

ISSN: 1465-542X

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