Fig. 6
From: Secreted indicators of androgen receptor activity in breast cancer pre-clinical models
Predictive value of candidate gene expression in TNBC subtypes. a TNBC samples from the SCAN-B and TCGA cohorts were classified into Lehmann's molecular subtypes, with samples characterized as being either LAR (luminal AR TNBC subtype) or non-LAR TNBC. The distribution of TNBC subtypes in each cohort is indicated. b GSEA was performed on LAR vs non-LAR to examine the relationship between TNBC subtype and the androgen responsive gene set. Enrichment plots with normal enrichment scores (NES) and p values for each cohort. c AR and candidate gene expression in LAR vs non-LAR are shown. d ROC curves of a given gene as a classifier for LAR with area under the ROC curve (AUC) analyses. The diagonal line denotes the ROC curve of a random classifier of AUC = 0.5. p value tests the null hypothesis that the AUC really equals 0.50