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Fig. 7 | Breast Cancer Research

Fig. 7

From: An immune-humanized patient-derived xenograft model of estrogen-independent, hormone receptor positive metastatic breast cancer

Fig. 7

Tumor microenvironment of immune-humanized HCI-013EI PDX models. a Representative images showing histology of HE, ER, msCD31, hCD45, hCD11b and hCD20 stains in immune-humanized HCI-013EI PDX tumors from Fig. 6. b Quantification of a of all humanized mice showing intratumoral hCD45+ cells (left), hCD11b+ cells (middle), and hCD20+ cells (right) as percentages of total detected cells. c Representative image of double IF staining of the same tumors as in a showing hCD45 (green), and hCD11b+ cells (red). d Quantification of e showing hCD11b+ and hCD11b− cells as percentages of total hCD45+ cells detected in HCI-013EI PDX tumors of humanized mice. Note that the presence of tumor-infiltrating human myeloid cells was often found to localize within the core of HCI-013EI tumors

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