Skip to main content
Fig. 4 | Breast Cancer Research

Fig. 4

From: Quantitative single-cell analysis of immunofluorescence protein multiplex images illustrates biomarker spatial heterogeneity within breast cancer subtypes

Fig. 4

MxIF co-expression patterns of Ki67, P53, P21 and P16 in breast cancer cores with corresponding IHC evaluation. The fractions of MxIF-measured Ki67-positive cells (Ki67 pos fraction), P53-positive cells (P53 pos fraction, P16-positive cells (P16 pos fraction) and P21-positive cells (P21 pos fraction) per core, and the distribution of normalized MxIF signal intensities of P53 (P53norm), p16 (P16norm) and P21 (P21norm) in single cells are shown across all cores as classified by IHC-surrogate subtypes. The IHC status of P53 and P16 are also evaluated and presented with solid color box representing normal, “X” indicates the presence of null expression for P53 and “O” indicates the presence of overexpression of P53 or P16

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us