A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans

Ibrahim, Ayman M.; Bilsland, Alan; Rickelt, Steffen; Morris, Joanna S.; Stein, Torsten

doi:10.1186/s13058-021-01470-3

Table 2 Matrisome-encoding RNAs with differential expression in PAFs

From: A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans

Probe ID	Gene symbol	p-values (< 0.05)	Fold change Preg/Ctrl	Probe ID	Gene Symbol	p-values (< 0.05)	Fold change Preg/Ctrl
UP				ILMN_1225835	Mfap5	0.0296	1.75
ILMN_2635784	Gpc1	0.0001	3.74	ILMN_2774315	Col13a1	0.0300	2.21
ILMN_1247540	Vcan	0.0003	3.1	ILMN_1256970	Adamts18	0.0323	1.71
ILMN_1246127	Prss23	0.0013	2.34	ILMN_2617087	Egln1	0.0347	1.84
ILMN_2463181	Tnc	0.0016	2.38	ILMN_1227502	Il15ra	0.0357	1.53
ILMN_2753809	Mmp3	0.0023	2.12	ILMN_1230599	Adam23	0.0362	1.78
ILMN_1243254	Adam12	0.0030	2.24	ILMN_3008858	Ctsc	0.0371	1.94
ILMN_2463180	Tnc	0.0036	2.4	ILMN_3158499	Mdk	0.0410	1.54
ILMN_2683958	Col3a1	0.0055	1.96	ILMN_2766028	Postn	0.0452	1.67
ILMN_2455596	Adamts18	0.0060	3.23	ILMN_2492264	Wisp1	0.0467	1.81
ILMN_2819929	Plod2	0.0064	1.57	ILMN_2688912	F10	0.0485	1.9
ILMN_1216882	Postn	0.0068	1.9	ILMN_2725927	Serpina3g	0.0488	1.88
ILMN_2769918	Timp1	0.0081	1.72	ILMN_2680415	Sema6d	0.0493	1.61
ILMN_1234487	Angpt2	0.0086	2.44	ILMN_2710698	Fgf21	0.0498	1.53
ILMN_1213850	Col4a3	0.0087	1.82	DOWN
ILMN_3103896	Timp1	0.0091	1.78	ILMN_2486906	Wisp2	0.0001	− 3.31
ILMN_1221670	Col5a2	0.0092	2.29	ILMN_2686327	Gas6	0.0014	− 1.63
ILMN_2728729	Sdc4	0.0093	1.82	ILMN_2760019	Cxcl13	0.0015	− 2.7
ILMN_2735184	Col18a1	0.0116	2.71	ILMN_1231689	Sfrp1	0.0046	− 2.21
ILMN_2769884	Igf1	0.0119	1.43	ILMN_1229370	Podn	0.0094	− 2.85
ILMN_1253797	Slit2	0.0131	2.02	ILMN_1249485	S100g	0.0095	− 2.14
ILMN_2460257	Adam10	0.0154	1.7	ILMN_1219335	Igfbp3	0.0098	− 1.78
ILMN_2617090	Egln1	0.0166	1.84	ILMN_2851288	Ngfr	0.0121	− 1.73
ILMN_2731901	S100a4	0.0171	1.69	ILMN_1238597	Omd	0.0132	− 1.93
ILMN_2715840	C1qc	0.0172	1.79	ILMN_2595664	Dhh	0.0139	− 1.6
ILMN_1240458	Mfap2	0.0188	1.47	ILMN_2697220	Figf/Vegfd	0.0148	− 1.4
ILMN_2901626	Tnfref21	0.0212	1.95	ILMN_2773348	Bmp8a	0.0148	− 2.43
ILMN_2617086	Egln1	0.0224	1.69	ILMN_2461098	Plxnb2	0.0164	− 1.65
ILMN_2718204	Clec11a	0.0235	1.17	ILMN_2910653	Bmp8a	0.0183	− 2.35
ILMN_2671344	Adamts12	0.0242	1.65	ILMN_1251096	Spock2	0.0213	− 1.74
ILMN_1213777	Fgf10	0.0245	1.61	ILMN_2834379	Tgfbi	0.0252	− 1.73
ILMN_1260125	Fn1	0.0252	1.75	ILMN_1259632	Col20a1	0.0253	− 2.07
ILMN_2770429	Plod2	0.0252	1.73	ILMN_1252506	Fbn1	0.0261	− 2.63
ILMN_2638114	Ptn	0.0259	1.37	ILMN_2727503	Igfbp3	0.0297	− 2.63
ILMN_1239380	Leprel2	0.0280	1.71	ILMN_2507286	Tnfsf13b	0.0338	− 1.55
ILMN_2659151	Thbs1	0.0290	1.15	ILMN_2718401	Htra3	0.0392	− 1.82
ILMN_2486186	Tnfrsf1b	0.0291	1.75	ILMN_1234111	Vtn	0.0392	− 1.48
ILMN_1234413	Adamts12	0.0293	1.5	ILMN_1214439	Ltbp1	0.0426	− 1.51

The table shows the 74 probes (Probe ID), representing 64 different RNAs, that encode proteins associated with the Matrisome [16] and are differentially expressed (p < 0.05) in fibroblasts from 3-days pregnant mouse mammary glands (Preg) compared to fibroblasts isolated from age-matched virgin control glands (Ctrl). Probes have been ranked by decreasing fold-change and increasing p-value

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