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Fig. 7 | Breast Cancer Research

Fig. 7

From: A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans

Fig. 7

Kaplan–Meier analyses generated with KM plotter for the 18-gene signature in (A) all breast cancer patients, (B) ER-positive (ERpos) and (C) ER-negative cases (ERneg) using DMFS as endpoint and a 10-year cut-off. Patient cohorts were split using the combined median expression levels of all 18 genes with negative weighting for genes associated with good prognosis in the GOBO analysis. ‘High’ and ‘Low’ expression cut-offs were chosen automatically by KM-Plotter for best fit. Tables below each graph show the multivariate analysis results, performed in the presence of ER status (ESR1), Ki-67 (MKi67)- and HER2 status, and showing hazard ratios and 95%-confidence intervals. (D) Kaplan–Meier plots for the 18-gene signature, using progression-free survival as endpoint for the ovarian cancer set, and (E) time to first progression for the lung cancer dataset, as well as (F) for gastric cancer patients within KM-Plotter

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