Fig. 6

(A) List of the 18 genes of the shortened matrisome-signature after multiple testing correction with fold-change expression values used for the 18-gene signature. The average fold-change of multiple probes was used for Postn and Timp1 (*). The expression values for the seven RNAs below the double lines have been reversed to reflect their tumour suppressor-like behaviour as described in the text. (B) Kaplan–Meier analyses (DMFS) generated using the GOBO online tool and centroid correlation clustering for the shortened 18-gene matrisome signature (18-gene sig.) in all breast cancers, (C) the ER-positive (ER^pos) and (D) ER-negative (ER^neg) subgroup with associated multivariate analyses in the presence of other clinical parameters: size (> 20 mm), age (> 50 years), high grade (G3), LN-status (LN^neg) and ER-status (ER^pos). (E) Bar graph comparing LogRank p-values (-log10) from each KM-analysis in the total breast cancer set and all available subgroups obtained for either the 64-gene or 18-gene signature (DMFS). The actual p-value for the 18-gene signature for all tumours (red bar) was rounded down by the software to p = 0 as p ≤ 1e−13. Red dotted line shows LogRank p = 0.05 with increasing significance above the line