Table 3 Multi-state Model for Cause of Death, KPNC Cohort Stage I-III breast cancers, diagnosed 2000–2010

Age at diagnosis categories

21–39

Reference

Reference

Reference

40–49

0.81 (0.13,1.49)

1.09 (0.76, 1.42)

0.63 (0.21, 1.05)

50–54

1.03 (0.34,1.72)

0.97 (0.62, 1.32)

0.65 (0.21, 1.09)

55–59

1.04 (0.36,1.72)

1.11 (0.77, 1.45)

1.02 (0.61, 1.43)

60–64

1.34 (0.68,2.00)

1.30 (0.96, 1.64)

1.04 (0.63, 1.45)

65–69

1.88 (1.23,2.53)

1.19 (0.83, 1.55)

1.44 (1.04, 1.84)

70–74

3.40 (2.76,4.04)

1.65 (1.29, 2.01)

2.45 (2.06, 2.84)

75 + 

6.27 (5.64,6.90)

2.47 (2.15, 2.79)

4.02 (3.63, 4.41)

Race

White

Reference

Reference

Reference

Black

1.78 (1.55, 2.01)

1.27 (1.04, 1.50)

1.13 (0.92,1.34)

Asian/Pacific Islander

0.70 (0.37, 1.03)

0.77 (0.53, 1.01)

0.68 (0.44, 0.92)

Other/Unknown

1.04 (0.35, 2.43)

1.27 (0.13, 2.41)

0.96 (0.18, 2.10)

Smoking Status

Current

2.59 (2.32,2.86)

1.96 (1.71, 2.21)

3.08 (2.87, 3.29)

Former

1.36 (1.09,1.63)

1.33 (1.08, 1.58)

1.49 (1.28, 1.70)

Non-smoker

Reference

Reference

Reference

Unknown

2.28 (2.07,2.49)

2.29 (2.11, 2.47)

2.69 (2.52, 2.86)

History of CVD

No prior history

Reference

–

Reference

History of event

2.10 (1.89,2.31)

–

1.28 (1.11, 1.45)

Unknown

1.53 (1.19,1.87)

–

1.44 (1.17, 1.71)

HDL Cholesterol

 < 35

1.54 (1.14,1.94)

1.92 (1.59, 2.25)

1.91 (1.62, 2.20)

35–44

1.04 (0.79,1.29)

1.28 (1.07, 1.49)

1.14 (0.95, 1.33)

45–49

0.84 (0.54,1.14)

0.90 (0.65, 1.15)

1.04 (0.83, 1.25)

50–59

0.81 (0.58,1.04)

0.99 (0.80, 1.18)

0.97 (0.80, 1.14)

60 + 

Reference

Reference

Reference

Unknown

1.32 (1.06, 1.58)

1.57 (1.36, 1.78)

1.49 (1.27, 1.71)

Charlson comorbidity

0

Reference

–

Reference

1–2

1.44 (1.26,1.62)

–

1.54 (1.41, 1.67)

3 + 

2.28 (2.03,2.53)

–

2.55 (2.34, 2.76)

Grade

Well differentiated

Reference

Reference

Reference

Moderately differentiated

1.11 (0.90,1.32)

2.86 (2.51, 3.21)

1.18 (1.02, 1.34)

Poorly differentiated

1.45 (1.20,1.70)

4.34 (3.99, 4.69)

1.56 (1.37, 1.75)

Diffuse

1.05 (0.28,1.82)

4.59 (4.03, 5.15)

1.02 (0.43, 1.61)

Unknown

1.52 (1.24, 1.80)

2.63 (2.23, 3.03)

1.12 (0.89, 1.35)

Tumor size

 ≤ 2 cm

Reference

Reference

Reference

(2,5] cm

1.43 (1.25,1.61)

2.13 (1.96, 2.30)

1.38 (1.24, 1.52)

 > 5 cm

1.91 (1.57, 2.25)

3.19 (2.95, 3.43)

2.01 (1.75, 2.27)

Diffuse or Unknown

3.74 (3.20,4.28)

5.26 (4.92, 5.60)

2.91 (2.43, 3.39)

Lymph Nodes Involved

0

Reference

Reference

Reference

1–3

1.23 (1.03,1.43)

1.71 (1.54, 1.88)

1.13 (0.98, 1.28)

4–9

1.51 (1.21,1.81)

3.04 (2.83, 3.25)

1.55 (1.32, 1.78)

10 + 

2.35 (1.95,2.75)

6.48 (6.25, 6.71)

1.90 (1.58, 2.22)

Unknown

2.52 (1.51,3.53)

2.13 (0.72, 3.54)

–

Radiation

0.82 (0.64,0.99)

–

0.87 (0.73, 1.01)

Chemotherapy

0.77 (0.55,0.99)

–

0.83 (0.66, 1.00)

Surgery

None

1.95 (1.59,2.31)

3.25 (2.95, 3.55)

1.98 (1.69, 2.27)

Lumpectomy

Reference

Reference

Reference

Mastectomy

1.05 (0.88,1.22)

1.33 (1.17, 1.49)

1.07 (0.94, 1.20)

Unknown

3.35 (1.93,4.77)

1.96 (0.03, 3.95)

–

ER/PR

Positive

0.82 (0.59,1.05)

0.48 (0.31, 0.65)

0.77 (0.60, 0.94)

Negative

Reference

Reference

Reference

Unknown/not done

0.67 (0.41,0.93)

0.53 (0.34, 0.72)

0.63 (0.43, 0.83)