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Table 3 Multi-state Model for Cause of Death, KPNC Cohort Stage I-III breast cancers, diagnosed 2000–2010

From: Modeling risks of cardiovascular and cancer mortality following a diagnosis of loco-regional breast cancer

  CVD Mortality
696 events
HR (95%CI)
Breast Cancer
Mortality
842 events
HR (95% CI)
All Other Causes
1191 events
HR (95%CI)
Age at diagnosis categories
21–39 Reference Reference Reference
40–49 0.81 (0.13,1.49) 1.09 (0.76, 1.42) 0.63 (0.21, 1.05)
50–54 1.03 (0.34,1.72) 0.97 (0.62, 1.32) 0.65 (0.21, 1.09)
55–59 1.04 (0.36,1.72) 1.11 (0.77, 1.45) 1.02 (0.61, 1.43)
60–64 1.34 (0.68,2.00) 1.30 (0.96, 1.64) 1.04 (0.63, 1.45)
65–69 1.88 (1.23,2.53) 1.19 (0.83, 1.55) 1.44 (1.04, 1.84)
70–74 3.40 (2.76,4.04) 1.65 (1.29, 2.01) 2.45 (2.06, 2.84)
75 +  6.27 (5.64,6.90) 2.47 (2.15, 2.79) 4.02 (3.63, 4.41)
Race
White Reference Reference Reference
Black 1.78 (1.55, 2.01) 1.27 (1.04, 1.50) 1.13 (0.92,1.34)
Asian/Pacific Islander 0.70 (0.37, 1.03) 0.77 (0.53, 1.01) 0.68 (0.44, 0.92)
Other/Unknown 1.04 (0.35, 2.43) 1.27 (0.13, 2.41) 0.96 (0.18, 2.10)
Smoking Status
Current 2.59 (2.32,2.86) 1.96 (1.71, 2.21) 3.08 (2.87, 3.29)
Former 1.36 (1.09,1.63) 1.33 (1.08, 1.58) 1.49 (1.28, 1.70)
Non-smoker Reference Reference Reference
Unknown 2.28 (2.07,2.49) 2.29 (2.11, 2.47) 2.69 (2.52, 2.86)
History of CVD
No prior history Reference Reference
History of event 2.10 (1.89,2.31) 1.28 (1.11, 1.45)
Unknown 1.53 (1.19,1.87) 1.44 (1.17, 1.71)
HDL Cholesterol
 < 35 1.54 (1.14,1.94) 1.92 (1.59, 2.25) 1.91 (1.62, 2.20)
35–44 1.04 (0.79,1.29) 1.28 (1.07, 1.49) 1.14 (0.95, 1.33)
45–49 0.84 (0.54,1.14) 0.90 (0.65, 1.15) 1.04 (0.83, 1.25)
50–59 0.81 (0.58,1.04) 0.99 (0.80, 1.18) 0.97 (0.80, 1.14)
60 +  Reference Reference Reference
Unknown 1.32 (1.06, 1.58) 1.57 (1.36, 1.78) 1.49 (1.27, 1.71)
Charlson comorbidity
0 Reference Reference
1–2 1.44 (1.26,1.62) 1.54 (1.41, 1.67)
3 +  2.28 (2.03,2.53) 2.55 (2.34, 2.76)
Grade
Well differentiated Reference Reference Reference
Moderately differentiated 1.11 (0.90,1.32) 2.86 (2.51, 3.21) 1.18 (1.02, 1.34)
Poorly differentiated 1.45 (1.20,1.70) 4.34 (3.99, 4.69) 1.56 (1.37, 1.75)
Diffuse 1.05 (0.28,1.82) 4.59 (4.03, 5.15) 1.02 (0.43, 1.61)
Unknown 1.52 (1.24, 1.80) 2.63 (2.23, 3.03) 1.12 (0.89, 1.35)
Tumor size
 ≤ 2 cm Reference Reference Reference
(2,5] cm 1.43 (1.25,1.61) 2.13 (1.96, 2.30) 1.38 (1.24, 1.52)
 > 5 cm 1.91 (1.57, 2.25) 3.19 (2.95, 3.43) 2.01 (1.75, 2.27)
Diffuse or Unknown 3.74 (3.20,4.28) 5.26 (4.92, 5.60) 2.91 (2.43, 3.39)
Lymph Nodes Involved
0 Reference Reference Reference
1–3 1.23 (1.03,1.43) 1.71 (1.54, 1.88) 1.13 (0.98, 1.28)
4–9 1.51 (1.21,1.81) 3.04 (2.83, 3.25) 1.55 (1.32, 1.78)
10 +  2.35 (1.95,2.75) 6.48 (6.25, 6.71) 1.90 (1.58, 2.22)
Unknown 2.52 (1.51,3.53) 2.13 (0.72, 3.54)
Radiation 0.82 (0.64,0.99) 0.87 (0.73, 1.01)
Chemotherapy 0.77 (0.55,0.99) 0.83 (0.66, 1.00)
Surgery
None 1.95 (1.59,2.31) 3.25 (2.95, 3.55) 1.98 (1.69, 2.27)
Lumpectomy Reference Reference Reference
Mastectomy 1.05 (0.88,1.22) 1.33 (1.17, 1.49) 1.07 (0.94, 1.20)
Unknown 3.35 (1.93,4.77) 1.96 (0.03, 3.95)
ER/PR
Positive 0.82 (0.59,1.05) 0.48 (0.31, 0.65) 0.77 (0.60, 0.94)
Negative Reference Reference Reference
Unknown/not done 0.67 (0.41,0.93) 0.53 (0.34, 0.72) 0.63 (0.43, 0.83)