Fig. 3

CD44 expression correlates with different transcriptome patterns in organ-derived cell lines. Differentially expressed genes for A CD44^high (red) and CD44^low (blue) EpCAM^high cells (across all samples) were used to generate GO terms. CD44^low cells exhibited high levels of expression for genes relevant to tumor microenvironment remodeling and tumor dormancy markers. CD44^high cells exhibited higher levels of gene expression associated with GO terms related to cellular proliferation, tumor aggression, and EMT. Differentially expressed genes and associated GO terms for CD44^high/low EpCAM^high cells from B lymph nodes and C lungs are also shown. For A–C, the − log(P value) scale applies to both the CD44^high (red) and CD44^low (blue) samples