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Fig. 3 | Breast Cancer Research

Fig. 3

From: Transcriptome analysis of heterogeneity in mouse model of metastatic breast cancer

Fig. 3

CD44 expression correlates with different transcriptome patterns in organ-derived cell lines. Differentially expressed genes for A CD44high (red) and CD44low (blue) EpCAMhigh cells (across all samples) were used to generate GO terms. CD44low cells exhibited high levels of expression for genes relevant to tumor microenvironment remodeling and tumor dormancy markers. CD44high cells exhibited higher levels of gene expression associated with GO terms related to cellular proliferation, tumor aggression, and EMT. Differentially expressed genes and associated GO terms for CD44high/low EpCAMhigh cells from B lymph nodes and C lungs are also shown. For AC, the − log(P value) scale applies to both the CD44high (red) and CD44low (blue) samples

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