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Table 5 Joint hazard ratios for incident CAD events in interaction models adjusted for baseline mediators

From: Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study

Interaction model Joint hazard ratio (95% CI)
With BMI* 1 Unit Increase in PRS
log(BMI) (Reference) 1.31 (1,18, 1.46)
1 Unit Increase in log(BMI) 1.40 (1.24, 1.58)
With smoking  
Never (Reference) 1.24 (1.06, 1.44)
Past smoker 1.52 (1.29, 1.79)
Current smoker 1.27 (1.03, 1.58)
  1. Baseline mediators include age, genotype array, 8 genetic PCs, log(BMI), smoking, education level, drinking, parity, hormone replacement therapy
  2. *log(BMI) was scaled to its mean