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Table 3 Hazard ratios for incident CAD events in sequential models adjusted for baseline mediators

From: Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study

Variable Model 1
(n = 8946;
d = 432)*
Model 2 Model 3 Model 4 Model 5 Model 5
P value
PRS 1.36
(1.23, 1.51)
1.34
(1.21, 1.49)
1.34
(1.21, 1.48)
1.33
(1.20, 1.48)
1.33
(1.20,1.47)
7.6 × 10–9
Age at diagnosis 1.10
(1.09, 1.13)
1.10
(1.09, 1.13)
1.10
(1.08, 1.12)
1.10
(1.08, 1.12)
1.10
(1.08, 1.12)
2.6 × 10–32
Log(BMI) 4.70
(2.79, 7.92)
3.59
(2.10, 6.10)
3.59
(2.08, 6.20)
3.62
(2.09, 6.24)
3.6 × 10–6
Past smoker 1.35
(1.08, 1.67)
1.35
(1.08, 1.68)
1.33
(1.06, 1.65)
1.32
(1.06, 1.64)
0.011
Current smoker 1.88
(1.45, 2.45)
1.74
(1.33, 2.28)
1.70
(1.30, 2.22)
1.70
(1.30, 2.22)
9.1 × 10–5
GSCE education 0.73
(0.58, 0.93)
0.74
(0.58, 0.93)
0.74
(0.58, 0.94)
0.011
A-level education 0.75
(0.52, 1.07)
0.77
(0.53, 1.10)
0.77
(0.54, 1.10)
0.15
Graduate education 0.68
(0.45, 1.02)
0.69
(0.46, 1.04)
0.69
(0.46, 1.04)
0.074
Drinking 0.71
(0.57, 0.86)
0.71
(0.58, 0.87)
0.72
(0.58, 0.88)
9.3 × 10–4
Log(IMD) 1.09
(0.94, 1.26)
1.08
(0.93, 1.25)
1.08
(0.93, 1.25)
0.29
Age at menarche - 0.99
(0.93, 1.06)
0.99
(0.93, 1.06)
0.86
Parity - 1.08
(0.99, 1.16)
1.08
1.00, 1.17)
0.049
Hormone replacement therapy - 1.20
(0.98, 1.46)
1.20
(0.98, 1.46)
0.068
Thyroid disease - 1.02
(0.77, 1.36)
1.03
(0.77, 1.37)
0.85
Chemotherapy 0.98
(0.77, 1.24)
0.86
Radiotherapy 0.91
(0.73, 1.14)
0.42
Hormone therapy 0.87
(0.68, 1.11)
0.25
  1. *All models were fit on the same sample. Model 1 represents the “baseline” model of PRS adjusted for age, genotype array and 8 genetic PCs. Model 2 is model 1 additionally adjusted for conventional risk factors of BMI and smoking. Model 3 is Model 2 additionally adjusted for other sociodemographic variables. Model 4 is Model 3 additionally adjusted for medical variables. Model 5 is Model 4 additionally adjusted for oncotherapies