Table 3 Hazard ratios for incident CAD events in sequential models adjusted for baseline mediators

PRS

1.36

(1.23, 1.51)

1.34

(1.21, 1.49)

1.34

(1.21, 1.48)

1.33

(1.20, 1.48)

1.33

(1.20,1.47)

7.6 × 10^–9

Age at diagnosis

1.10

(1.09, 1.13)

1.10

(1.09, 1.13)

1.10

(1.08, 1.12)

1.10

(1.08, 1.12)

1.10

(1.08, 1.12)

2.6 × 10^–32

Log(BMI)

–

4.70

(2.79, 7.92)

3.59

(2.10, 6.10)

3.59

(2.08, 6.20)

3.62

(2.09, 6.24)

3.6 × 10^–6

Past smoker

–

1.35

(1.08, 1.67)

1.35

(1.08, 1.68)

1.33

(1.06, 1.65)

1.32

(1.06, 1.64)

0.011

Current smoker

–

1.88

(1.45, 2.45)

1.74

(1.33, 2.28)

1.70

(1.30, 2.22)

1.70

(1.30, 2.22)

9.1 × 10^–5

GSCE education

–

–

0.73

(0.58, 0.93)

0.74

(0.58, 0.93)

0.74

(0.58, 0.94)

0.011

A-level education

–

–

0.75

(0.52, 1.07)

0.77

(0.53, 1.10)

0.77

(0.54, 1.10)

0.15

Graduate education

–

–

0.68

(0.45, 1.02)

0.69

(0.46, 1.04)

0.69

(0.46, 1.04)

0.074

Drinking

–

–

0.71

(0.57, 0.86)

0.71

(0.58, 0.87)

0.72

(0.58, 0.88)

9.3 × 10^–4

Log(IMD)

–

–

1.09

(0.94, 1.26)

1.08

(0.93, 1.25)

1.08

(0.93, 1.25)

0.29

Age at menarche

-

–

–

0.99

(0.93, 1.06)

0.99

(0.93, 1.06)

0.86

Parity

-

–

–

1.08

(0.99, 1.16)

1.08

1.00, 1.17)

0.049

Hormone replacement therapy

-

–

–

1.20

(0.98, 1.46)

1.20

(0.98, 1.46)

0.068

Thyroid disease

-

–

–

1.02

(0.77, 1.36)

1.03

(0.77, 1.37)

0.85

Chemotherapy

–

–

–

–

0.98

(0.77, 1.24)

0.86

Radiotherapy

–

–

–

–

0.91

(0.73, 1.14)

0.42

Hormone therapy

–

–

–

–

0.87

(0.68, 1.11)

0.25