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Table 1 Genotyped participant characteristics by incident CAD outcome observed during follow-up

From: Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study

  SEARCH Experienced incident CAD Did not experience incident CAD
  N = 12,413 N = 750 N = 11,663
Age at diagnosis 54.6 (8.9) 59.9 (7.1) 54.2 (8.9)
Received adjuvant chemotherapy 4735 (38%) 202 (27%) 4533 (39%)
Received adjuvant radiotherapy 8773 (71%) 535 (71%) 8238 (71%)
Received adjuvant hormonal therapy 9496 (77%) 580 (77%) 8916 (76%)
Histopathological grade /10859 /10207 /652
Well Differentiated 2088 (19%) 132 (20%) 1956 (19%)
Moderately Differentiated 5364 (49%) 351 (54%) 5013 (49%)
Poorly/Undifferentiated 3407 (31%) 169 (26%) 3238 (32%)
Tumor maximum diameter (mm)* 17 [11, 24] 15.5 [10, 23] 17 [11, 24]
(Missing) 2655 156 2499
Number of nodes excised* 8 [4, 14] 8 [4,13] 8 [4, 14]
(Missing) 2934 170 2764
Number of nodes involved* 0 [0, 1] 0 [0, 1] 0 [0, 1]
(Missing) 3219 198 3021
ER Status /9150 /548 /8602
Negative 1474 (16%) 80 (15%) 1394 (16%)
Positive 7676 (84%) 468 (85%) 7208 (84%)
Highest level of education received /11196 /666 /10530
Below GSCE 2376 (21%) 238 (36%) 2138 (20%)
GSCE or similar 5721 (51%) 322 (48%) 5399 (51%)
A-level or similar 1493 (13%) 54 (8.1%) 1439 (14%)
Graduate 1606 (14%) 52 (7.8%) 1554 (15%)
Index of Multiple Deprivation 13.7 (9.4) 15.1 (10.1) 13.6 (9.3)
Age at menarche 12.8 (1.6) 12.8 (1.7) 12.8 (1.5)
(Missing) 1463 73 1390
Number of full-term pregnancies* 2 [1, 2] 2 [1, 3] 2 [1, 2]
(Missing) 5 0 5
Height (cm) 204 (167) 190 (138) 205 (168)
Weight (kg) 109 (171) 107 (157) 109 (172)
BMI (kg/m2) 26.8 (5.2) 28.6 (5.6) 26.7 (5.2)
(Missing) 830 39 791
Received hormonal replacement therapy 4762/11888 (40%) 381/728 (52%) 4381/11160 (39%)
Smoking history /11815 /719 /11096
Never 6363 (54%) 305 (42%) 6058 (55%)
Past 3534 (30%) 262 (36%) 3272 (29%)
Current, in last year 1918 (16%) 152 (21%) 1766 (16%)
Alcohol Consumption /12413 /750 /11663
Past 4290 (35%) 341 (45%) 3949 (34%)
Current 8123 (65%) 409 (55%) 7714 (66%)
Ethnicity /11980 /731 /11249
European 11,955 (~ 100%) 730 (~ 100%) 11,225 (~ 100%)
African 1 (< 0.1%) 0 1 (< 0.1%)
Asian 2 (< 0.1%) 1 (0.1%) 1 (< 0.1%)
Southeast Asian 0 0 0
Other 22 (0.2%) 0 22 (0.2%)
Thyroid disease 1288/11874 (11%) 115/724 (16%) 1173/11150 (11%)
  1. Mean (SD) is presented for continuous variables. n/N (%) is presented for categorical variables. Median [p25, p75] is presented for count variables