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Table 1 Genotyped participant characteristics by incident CAD outcome observed during follow-up

From: Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study

 

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Experienced incident CAD

Did not experience incident CAD

 

N = 12,413

N = 750

N = 11,663

Age at diagnosis

54.6 (8.9)

59.9 (7.1)

54.2 (8.9)

Received adjuvant chemotherapy

4735 (38%)

202 (27%)

4533 (39%)

Received adjuvant radiotherapy

8773 (71%)

535 (71%)

8238 (71%)

Received adjuvant hormonal therapy

9496 (77%)

580 (77%)

8916 (76%)

Histopathological grade

/10859

/10207

/652

Well Differentiated

2088 (19%)

132 (20%)

1956 (19%)

Moderately Differentiated

5364 (49%)

351 (54%)

5013 (49%)

Poorly/Undifferentiated

3407 (31%)

169 (26%)

3238 (32%)

Tumor maximum diameter (mm)*

17 [11, 24]

15.5 [10, 23]

17 [11, 24]

(Missing)

2655

156

2499

Number of nodes excised*

8 [4, 14]

8 [4,13]

8 [4, 14]

(Missing)

2934

170

2764

Number of nodes involved*

0 [0, 1]

0 [0, 1]

0 [0, 1]

(Missing)

3219

198

3021

ER Status

/9150

/548

/8602

Negative

1474 (16%)

80 (15%)

1394 (16%)

Positive

7676 (84%)

468 (85%)

7208 (84%)

Highest level of education received

/11196

/666

/10530

Below GSCE

2376 (21%)

238 (36%)

2138 (20%)

GSCE or similar

5721 (51%)

322 (48%)

5399 (51%)

A-level or similar

1493 (13%)

54 (8.1%)

1439 (14%)

Graduate

1606 (14%)

52 (7.8%)

1554 (15%)

Index of Multiple Deprivation

13.7 (9.4)

15.1 (10.1)

13.6 (9.3)

Age at menarche

12.8 (1.6)

12.8 (1.7)

12.8 (1.5)

(Missing)

1463

73

1390

Number of full-term pregnancies*

2 [1, 2]

2 [1, 3]

2 [1, 2]

(Missing)

5

0

5

Height (cm)

204 (167)

190 (138)

205 (168)

Weight (kg)

109 (171)

107 (157)

109 (172)

BMI (kg/m2)

26.8 (5.2)

28.6 (5.6)

26.7 (5.2)

(Missing)

830

39

791

Received hormonal replacement therapy

4762/11888 (40%)

381/728 (52%)

4381/11160 (39%)

Smoking history

/11815

/719

/11096

Never

6363 (54%)

305 (42%)

6058 (55%)

Past

3534 (30%)

262 (36%)

3272 (29%)

Current, in last year

1918 (16%)

152 (21%)

1766 (16%)

Alcohol Consumption

/12413

/750

/11663

Past

4290 (35%)

341 (45%)

3949 (34%)

Current

8123 (65%)

409 (55%)

7714 (66%)

Ethnicity

/11980

/731

/11249

European

11,955 (~ 100%)

730 (~ 100%)

11,225 (~ 100%)

African

1 (< 0.1%)

0

1 (< 0.1%)

Asian

2 (< 0.1%)

1 (0.1%)

1 (< 0.1%)

Southeast Asian

0

0

0

Other

22 (0.2%)

0

22 (0.2%)

Thyroid disease

1288/11874 (11%)

115/724 (16%)

1173/11150 (11%)

  1. Mean (SD) is presented for continuous variables. n/N (%) is presented for categorical variables. Median [p25, p75] is presented for count variables