Fig. 5
From: Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models
FGFR2 and FGFR4 alterations in breast cancer patients. a Frequency of FGFR2 and FGFR4 alterations in different breast cancer subtypes. Data were extracted from the METABRIC dataset in cBioPortal. Only patients with FGFR alterations are displayed for brevity. b Immunohistochemical staining for FGFR4 on breast cancer specimens. PDX HCI-009 and ELX11-26 were used as positive and negative controls, respectively. A cohort of 12 luminal breast cancer and 13 TNBC samples were stained for FGFR4 expression. The frequency of positive and negative staining in these cohorts is represented in the bar graphs. c Association of FGFR4 alterations with patient prognosis. Kaplan–Meier plots using data from the METABRIC dataset indicating that patients with FGFR4 overexpression (left panel) or amplification (right panel) exhibit worse overall survival compared to those without FGFR4 alteration. A Logrank test was used where a p value of < 0.05 was considered significant. Survival data for the different patient groups were extracted and downloaded from cBioPortal and survival analysis performed using an in-house Matlab script