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Table 1 Participant characteristics according to 38-gene HGF signature expression, Carolina Breast Cancer Study, 1993–2013

From: Hepatocyte growth factor pathway expression in breast cancer by race and subtype

  HGF negative, N (%) HGF positive, N (%) Univariate RFD (95% CI) Multivariable RFD (95% CI)
Total 1329 (68%) 628 (32%)   
Agea     
 < 40 years old 1522 (53%) 100 (47%) 21.25% (14.81, 27.68) 20.33% (14.05, 26.61)
 40–49 years old 498 (66%) 257 (34%) 8.25% (3.84, 12.66) 8.51% (4.29, 15.98)
 ≥ 50 years 679 (74%) 236 (26%) Referent Referent
Raceb     
 Black 603 (58%) 430 (42%) 20.20% (16.19, 24.20) 19.93% (16.00, 23.87)
 Non-black 726 (79%) 198 (21%) Referent Referent
Gradec     
 III 337 (47%) 384 (53%) 43.94% (39.76, 48.13) 41.11% (36.68, 45.55)
 I/II 691 (91%) 71 (9%) Referent Referent
Stagec     
 Stage III/IV 208 (64%) 115 (36) 11.56% (5.39, 17.71) 6.16% (0.21, 12.11)
 Stage II 605 (63%) 349 (37%) 12.53% (8.06, 17.01) 7.89% (3.54, 12.22)
 Stage I 499 (76%) 158 (24%) Referent Referent
Postmenopausal BMIc     
 Obese 356 (73%) 132 (27%) − 1.97 (− 9.10, 5.16), − 6.23 (− 13.38, 0.92)
 Overweight 209 (73%) 76 (27%) − 2.35 (− 10.20, 5.50) − 3.71 (− 11.24, 3.83)
 Underweight/normal 159 (71%) 65 (29%) Referent Referent
Premenopausal BMIc     
 Obese 225 (56%) 176 (44%) 16.07 (8.95, 23.20) 5.70% (− 1.68, 13.09)
 Overweight 162 (65%) 86 (35%) 6.86 (− 1.02, 14.75) 2.62% (− 4.87, 10.11)
 Underweight/normal 205 (72%) 79 (28%) Referent Referent
Reproductive historyc     
 Nulliparous 213 (71%) 85 (29%) − 9.04% (− 15.07, − 3.02) − 7.18% (− 12.91, − 1.46)
 Parous, breastfed 551 (73%) 203 (27%) − 10.64% (− 15.11, − 6.18) − 6.77% (− 11.09, − 2.45)
 Parous, never breastfed 565 (62%) 340 (38%) Referent Referent
Family history of breast cancerc     
 Yes 235 (68%) 110 (32%) − 0.18% (− 5.62, 5.26) 1.14.% (− 3.96, 6.25)
 No 1053 (68%) 497 (32%) Referent Referent
  1. aRelative frequency differences (RFDs) adjusted for race
  2. bAdjusted for age
  3. cAdjusted for race and age