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Fig. 8 | Breast Cancer Research

Fig. 8

From: Sensitivity to targeted therapy differs between HER2-amplified breast cancer cells harboring kinase and helical domain mutations in PIK3CA

Fig. 8

Kinase domain mutant or PTEN-loss samples have significantly lower expression of ERBB2 and GRB7, by Mann-Whitney analysis. A Boxplots comparing expression levels of ERBB2 mRNA (top) or GRB7 mRNA (bottom) between wildtype PIK3CA samples and either mutant group in RNAseq data from TCGA. ***P value < 0.0001. B Boxplots of RPPA data for amount of HER2 protein in wildtype PIK3CA samples and either mutant group. *P value < 0.001. C Boxplots comparing expression levels of ERBB2 (top) or GRB7 (bottom) between wildtype PIK3CA samples and either mutant group in RNAseq data from METABRIC. *P value < 0.01

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Breast Cancer Research

ISSN: 1465-542X

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