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Table 7 Combined effect of chest X-ray exposure and genetic variants

From: Diagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation

Chest X-ray exposure & number of DNA repair rare variants Number of    Multiple imputation
Cases Ctrls ORa 95%CI ORa 95%CI
Group ‘Low’b
 Ever & 0 variant 604 580 1   1  
 Ever & 1 variant 197 288 0.67 0.52-0.86 0.67 0.52-0.87
 Ever & 2 variants 34 69 0.52 0.32-0.84 0.49 0.30-0.79
 Ever & ≥3 variants 3 14 0.25 0.06-1.00 0.25 0.06-0.99
 Never 135 195 0.50 0.37-0.68 0.31 0.18-0.52
 Continuouse    0.69 0.57-0.84 0.69 0.58-0.83
 Never & 0 variant 101 128 1   1  
 Never & 1 variant 27 50 0.56 0.30-1.06 0.56 0.30-1.05
 Never & 2 variants 7 16 0.52 0.17-1.57 0.48 0.16-1.44
 Never & ≥3 variants 0 1 -   -  
 Ever & 0 variant 604 580 1.67 1.19-2.34 1.66 1.18-2.34
 Ever & 1 variant 197 288 1.12 0.77-1.62 1.12 0.77-1.64
 Ever & 2 variants 34 69 0.86 0.50-1.51 0.82 0.46-1.43
 Ever &≥3 variants 3 14 0.42 0.10-1.71 0.42 0.10-1.71
Group ‘No Effect’c
 Ever & 0 variant 484 535 1   1  
 Ever & 1 variant 258 318 0.96 0.76-1.22 0.97 0.76-1.23
 Ever & 2 variants 81 78 1.12 0.76-1.65 1.15 0.77-1.70
 Ever & ≥3 variants 15 20 1.21 0.55-2.70 1.28 0.57-2.87
 Never 135 195 0.58 0.43-0.78 0.61 0.40-0.94
 Continuouse    1.02 0.86-1.21 1.05 0.90-1.21
 Never & 0 variant 74 114 1   1  
 Never & 1 variant 45 67 1.08 0.62-1.90 1.08 0.61-1.89
 Never & 2 variants 14 12 1.40 0.55-3.59 1.50 0.59-3.84
 Never & ≥3 variants 2 2 1.90 0.23-15.8 1.93 0.23-16.1
 Ever & 0 variant 484 535 1.85 1.27-2.70 1.85 1.27-2.71
 Ever & 1 variant 258 318 1.77 1.19-2.65 1.78 1.19-2.66
 Ever & 2 variants 81 78 2.07 1.25-3.42 2.13 1.29-3.54
 Ever & ≥3 variants 15 20 2.24 0.95-5.32 2.39 1.01-5.64
Group ‘High’d
 Ever & 0 variant 343 551 1   1  
 Ever & 1 variant 327 291 2.06 1.62-2.63 2.07 1.62-2.65
 Ever & 2 variants 122 93 2.34 1.66-3.31 2.28 1.60-3.23
 Ever & ≥3 variants 46 16 4.61 2.34-9.08 4.65 2.35-9.22
 Never 135 195 0.85 0.63-1.16 0.74 0.49-1.13
 Continuouse    1.67 1.42-1.96 1.66 1.44-1.90
 Never & 0 variant 70 104 1   1  
 Never & 1 variant 46 62 0.90 0.51-1.58 0.88 0.50-1.54
 Never & 2 variants 13 23 0.66 0.27-1.57 0.58 0.24-1.41
 Never & ≥3 variants 6 6 2.01 0.54-7.48 2.01 0.54-7.45
 Ever & 0 variant 343 551 1.12 0.75-1.65 1.10 0.75-1.63
 Ever & 1 variant 327 291 2.30 1.54-3.44 2.28 1.53-3.40
 Ever & 2 variants 122 93 2.61 1.63-4.19 2.51 1.56-4.03
 Ever & ≥3 variants 46 16 5.15 2.43-10.9 5.10 2.41-10.8
  1. Abbreviations: OR (95%CI) odds ratio (95% confidence interval)
  2. aAdjusted for age at censoring, birth cohort (≤1945; 1946-1959; ≥1960), number of full-term pregnancies (>2; 1-2; 0), mammography use (never; ever), educational level (intermediate/high; basic; not graduated), BMI (18.5-24.99; <18.5; ≥25 and <30; ≥30), smoking (no; current; past), and two other DNA repair genes groups
  3. bat least one variant in a gene from Group ‘Low’
  4. cat least one variant in a gene from Group ‘No Effect’
  5. dat least one variant in a gene from Group ‘High’
  6. e“Never” excluded