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Table 2 Characteristics of GENESIS participants

From: Diagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation

Characteristics

Cases

N = 1,552

Controls

N = 1,363

No.

 %

No.

 %

Birth cohort

 ≤1945

488

31.4

294

21.6

 1946–59

797

51.4

706

51.8

 ≥1960

267

17.2

363

26.6

Age at censoring, years

 Mean (sd)

50.2 (9.3)

 

55.8 (9.9)

 

 ≤45

513

33.1

201

14.8

 46–50

336

21.7

197

14.5

 51–60

473

30.5

485

35.6

 >60

230

14.8

480

35.2

Education level

  

 Intermediate/high

780

50.3

916

67.2

 Basic

714

46.0

434

31.8

 Not graduated

58

3.7

12

0.9

 Missing

0

0.0

1

0.1

Body mass index

 18.5–24.9

1,019

65.6

869

63.8

 <18.5

69

4.5

32

2.3

 ≥25 and <30

341

22.0

345

25.3

 ≥30

120

7.7

117

8.6

 Missing

3

0.2

0

0.0

Smoking

 No

832

53.6

680

49.9

 Current

159

10.2

158

11.6

 Past

550

35.4

514

37.7

 Missing

11

0.7

11

0.8

Number of full term pregnancies

 ≥2

445

28.7

411

30.2

 1–2

921

59.3

763

56.0

 0

185

11.9

187

13.7

 Missing

1

0.1

2

0.1

Age at first full-term pregnancy, years

  

 <20

179

11.5

102

7.5

 20–24

628

40.5

531

39.0

 25–29

393

25.4

392

28.8

 ≥30

165

10.6

149

10.9

 No full-term pregnancy

185

11.9

187

13.7

 Missing

2

0.1

2

0.1

Family history of breast cancera

  

 None

427

27.5

959

70.4

 1st degree

818

52.7

187

13.7

 Only 2nd degree

307

19.8

216

15.9

 Missing

0

0.0

1

0.1

Tumor estrogen receptors (ER)

 ER+

818

52.7

  

 ER-

168

10.8

 Missing

566

36.5

Gene groupb

Group “Low”

 0

723

46.6

721

52.9

> 1

274

17.7

441

32.4

Group “No Effect”

 0

575

37.1

659

48.4

>1

422

27.2

503

36.9

Group “High”

 0

422

27.2

667

48.9

>1

575

37.1

495

36.3

Missing

555

35.8

201

14.8

  1. aExcluding one affected sister per index case, “none” means no history of BC for controls or no additional BC case in the family for cases; “1st degree” means 1st degree family history for controls or additional 1st degree relative for cases and “2nd degree” means only 2nd degree family history for controls or only additional 2nd degree family history for cases
  2. bIndividuals carrying at least one variant in one of the Gene Groups: Group “Low” (OR<0.9); Group “No Effect” (0.9≤OR≤1.1); Group “High” (OR>1.1)