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Table 2 Characteristics of GENESIS participants

From: Diagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation

Characteristics Cases
N = 1,552
Controls
N = 1,363
No.  % No.  %
Birth cohort
 ≤1945 488 31.4 294 21.6
 1946–59 797 51.4 706 51.8
 ≥1960 267 17.2 363 26.6
Age at censoring, years
 Mean (sd) 50.2 (9.3)   55.8 (9.9)  
 ≤45 513 33.1 201 14.8
 46–50 336 21.7 197 14.5
 51–60 473 30.5 485 35.6
 >60 230 14.8 480 35.2
Education level   
 Intermediate/high 780 50.3 916 67.2
 Basic 714 46.0 434 31.8
 Not graduated 58 3.7 12 0.9
 Missing 0 0.0 1 0.1
Body mass index
 18.5–24.9 1,019 65.6 869 63.8
 <18.5 69 4.5 32 2.3
 ≥25 and <30 341 22.0 345 25.3
 ≥30 120 7.7 117 8.6
 Missing 3 0.2 0 0.0
Smoking
 No 832 53.6 680 49.9
 Current 159 10.2 158 11.6
 Past 550 35.4 514 37.7
 Missing 11 0.7 11 0.8
Number of full term pregnancies
 ≥2 445 28.7 411 30.2
 1–2 921 59.3 763 56.0
 0 185 11.9 187 13.7
 Missing 1 0.1 2 0.1
Age at first full-term pregnancy, years   
 <20 179 11.5 102 7.5
 20–24 628 40.5 531 39.0
 25–29 393 25.4 392 28.8
 ≥30 165 10.6 149 10.9
 No full-term pregnancy 185 11.9 187 13.7
 Missing 2 0.1 2 0.1
Family history of breast cancera   
 None 427 27.5 959 70.4
 1st degree 818 52.7 187 13.7
 Only 2nd degree 307 19.8 216 15.9
 Missing 0 0.0 1 0.1
Tumor estrogen receptors (ER)
 ER+ 818 52.7   
 ER- 168 10.8
 Missing 566 36.5
Gene groupb
Group “Low”
 0 723 46.6 721 52.9
> 1 274 17.7 441 32.4
Group “No Effect”
 0 575 37.1 659 48.4
>1 422 27.2 503 36.9
Group “High”
 0 422 27.2 667 48.9
>1 575 37.1 495 36.3
Missing 555 35.8 201 14.8
  1. aExcluding one affected sister per index case, “none” means no history of BC for controls or no additional BC case in the family for cases; “1st degree” means 1st degree family history for controls or additional 1st degree relative for cases and “2nd degree” means only 2nd degree family history for controls or only additional 2nd degree family history for cases
  2. bIndividuals carrying at least one variant in one of the Gene Groups: Group “Low” (OR<0.9); Group “No Effect” (0.9≤OR≤1.1); Group “High” (OR>1.1)