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Fig. 1 | Breast Cancer Research

Fig. 1

From: Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland

Fig. 1

The response of mammary epithelial cell lineages to E + P (estrogen + progesterone) exposure is reversed by PR blockade. a Representative separation of cellular lineages by FACS. b Cell expansion was significantly attenuated in both TPA- (p < 0.010) and MFP- (p < 0.01) treated mice compared to MaSC in mice treated with EP alone. The LP cells show marked reduction in EP-treated mice (p < 0.01) compared to sham. LM cells show an expansion (p < 0.05) in EP-treated mice compared to sham (52.40%). TPA significantly (p < 0.01) suppresses LM cell expansion observed in the EP group. LP cells show significant expansion in both EP + TPA (p < 0.01) and EP + MFP (p < 0.05) group. The MaSc within the basal cell niche show significant expansion at day 15 when mice were sacrificed (p < 0.05) in mice implanted with E2 and P4 compared to sham. The relative percentage of cells stained were compared by one-way ANOVA and Tukey post hoc analysis to compare between specific groups. Parental cells are the CD24+ cells

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Breast Cancer Research

ISSN: 1465-542X

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