Fig. 8

Induction of Src family kinases and migration is not a general response to chemotherapies. MCF7 cells were treated with vehicle (DMSO) or doses of Camptothecin, Etoposide, or Taxol as shown. A Fyn and B Yes expression were analyzed by qRT-PCR with actin as a reference gene. Results on Dox from Fig. 5 shown to allow comparison. Data are shown as mean normalized expression (Mean ± SEM, *p < 0.05 vs veh, n = 4; results from Dox induced are not included in the statistical calculations). C Cells were seeded in 24-well plate, and a scratch was introduced in each well prior to treatment with Camptothecin or Taxol. Change in area of wound is shown