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Fig. 6 | Breast Cancer Research

Fig. 6

From: Sublethal doxorubicin promotes migration and invasion of breast cancer cells: role of Src Family non-receptor tyrosine kinases

Fig. 6

Dox induction of Fyn and Yes is dependent on p53. MCF7 and U-2OS cells were treated with siRNA, vehicle (DMSO) and 0.4 μM Dox as shown. (A) Protein was extracted and immunoblotted for p53 and Actin in MCF7 cells. (B-I) Allstars negative control (AS) or p53-siRNA-treated cells were analyzed for (B,F) p53 knockdown by immunoblot and (C,G) Fyn (D,H) Yes (E,I) Fgr expression by qRT-PCR analysis in MCF7 and U-2OS cells (Mean ± SEM, **p < 0.01 vs. si-AS, n = 4 in MCF7, n = 3 in U-2OS)

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Breast Cancer Research

ISSN: 1465-542X

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