Fig. 5
From: Transcriptome and genome evolution during HER2-amplified breast neoplasia
Transcriptomic and CNV profiles in DCIS_neg from HER2-negative patients. a Heatmap of the mean-centered expressions of genes involved in ECM organization and interaction in normal breast of HER2-negative patients (NL_neg), normal breast of HER2-positive patients (NL_pos), DCIS_neg, and DCIS_noamp. These enriched genes were identified by ToppFun analysis on the differentially up-regulated genes in comparison between DCIS_noamp and DCIS_neg. b Frequency of the CNVs detected in all DCIS_neg samples along the chromosome location. Red: gain; blue: loss. The red dotted line denotes the value of (Q3+1.5×IQR) as the threshold. 6q loss and 11q loss are called statistically significant in DCIS_neg