Fig. 2

Cis-effect of HER2 amplification in DCIS from HER2-positive patients. a Inferred DNA copy number on chromosome 17 in DCIS. Genes are aggregated in blocks of 0.5Mb by transcription termination site. Heatmap cells show expressions normalized to the mean of normal breast samples. Red: higher expression than normal breasts; blue: lower expression than normal breasts; gray: no data. The blue-dashed box is where HER2 locus and surrounding amplicon locate. The bright red line shows the position of the HER2 locus. b Heatmap of relative expressions of genes in the blue-dashed box from 2a. Heatmap cells show expressions normalized to the means of matched normal breast samples. Yellow: higher expression than normal breasts; blue: lower expression than normal breasts. The red rectangle denotes the amplicon by visualizing the gene heatmap