Adolescent and early adulthood inflammation-associated dietary patterns in relation to premenopausal mammographic density

Table 4 Mean percent mammographic density by dietary pattern tertile and stratified by BMI at mammogram

Percent mammographic density	T1	T2	T3	P_trend^c	P_interaction
Adolescent (n = 709)^a
Pro-inflammatory dietary pattern
BMI < 25	(n = 164)	(n = 151)	(n = 94)		0.57
BMI < 25	46.9 (43.9–49.9)	52.1 (49.0–55.3)	51.8 (46.5–57.0)	0.12
BMI ≥ 25	(n = 85)	(n = 109)	(n = 106)
BMI ≥ 25	29.4 (26.0–32.7)	29.0 (26.6–31.4)	31.7 (28.7–34.6)	0.32
AHEI dietary pattern
BMI < 25	(n = 129)	(n = 137)	(n = 143)		< 0.0001
BMI < 25	49.9 (46.8–53.0)	48.2 (45.6–50.8)	50.5 (48.1–53.0)	0.76
BMI ≥ 25	(n = 88)	(n = 113)	(n = 99)
BMI ≥ 25	30.6 (27.7–33.6)	30.8 (28.0–33.5)	27.9 (25.0–30.9)	0.34
Early adulthood (n = 1117)^b
Pro-inflammatory dietary pattern
BMI < 25	(n = 240)	(n = 205)	(n = 185)		0.05
BMI < 25	48.6 (46.5–50.8)	48.8 (46.7–50.8)	46.4 (44.3–48.5)	0.18
BMI ≥ 25	(n = 163)	(n = 155)	(n = 169)
BMI ≥ 25	30.8 (28.4–33.3)	31.5 (29.2–33.9)	31.2 (29.1–33.3)	0.82
AHEI dietary pattern
BMI < 25	(n = 196)	(n = 201)	(n = 233)		< 0.0001
BMI < 25	46.6 (44.6–48.6)	48.9 (47.0–50.8)	48.5 (46.2–50.7)	0.26
BMI ≥ 25	(n = 146)	(n = 167)	(n = 174)
BMI ≥ 25	31.0 (28.8–33.2)	32.2 (29.9–34.5)	30.4 (28.1–32.6)	0.65

^aAdjusted for adolescent total calorie intake, age at the time of mammogram, BMI at the time of mammogram, BMI at age 18 (kg/m²; cont.), adolescent physical activity (METs/week, 0–43, > 43), adolescent alcohol intake (drinker vs. non-drinkers), age at menarche (≤ 12; 13+ years), age at first birth (AFB) and parity combined (nulliparous; AFB < 25 years, 1–2 kids; AFB 25+ years, 1–2 kids; AFB any age, 3+ kids), history of biopsy-confirmed benign breast disease (yes; no), first-degree family history of breast cancer (yes; no)
^bAdjusted for early adulthood total calorie intake, age at the time of mammogram, BMI at the time of mammogram, BMI at age 18 (kg/m²; cont.), early adulthood physical activity (METs/week, 0–8, 9–26, 27+), early adulthood alcohol intake (0 g/day; 0.1 to < 5 g/day; 5+ g/day), age at menarche (< 12; 12; 13; 14+ years), age at first birth (AFB) and parity combined (nulliparous; AFB < 25 years, 1–2 kids; AFB 25+ years, 1–2 kids; AFB any age, 3+ kids), biopsy-confirmed benign breast disease (yes; no), first-degree family history of breast cancer (yes; no)
^cTrend test is based on the median of the category

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