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Table 2 Mean mammographic density phenotypes (95% confidence interval) by quintile of the adolescent dietary pattern (n = 709)

From: Adolescent and early adulthood inflammation-associated dietary patterns in relation to premenopausal mammographic density

Adolescent pro-inflammatory dietary pattern
  Q1 (lowest inflammation) Q2 (low inflammation) Q3 (moderate inflammation) Q4 (high inflammation) Q5 (highest inflammation) ptrendd
(n = 144) (n = 159) (n = 157) (n = 142) (n = 107)
Percent mammographic density
 Model 1a 41.7 (38.9–44.6) 42.8 (39.9–45.7) 42.8 (40.2–45.4) 40.9 (37.9–43.9) 34.8 (31.3–38.3) 0.005
 Model 2b 39.5 (37.2–41.8) 41.4 (38.9–44.0) 42.3 (40.0–44.6) 42.3 (39.8–44.9) 39.0 (35.9–42.0) 0.93
 Model 3c 39.6 (37.3–41.9) 41.3 (38.7–43.9) 42.0 (39.8–44.3) 42.9 (40.4–45.3) 38.7 (35.7–41.7) 0.93
Dense area in cm2
 Model 1a 43.6 (39.5–47.6) 43.5 (40.1–47.0) 43.8 (40.5–47.1) 46.8 (42.5–51.0) 41.6 (36.7–46.5) 0.97
 Model 2b 43.4 (39.3–47.5) 43.4 (40.0–46.9) 43.7 (40.4–47.0) 46.9 (42.6–51.1) 41.9 (37.2–46.7) 0.90
 Model 3c 43.5 (39.4–47.6) 43.0 (39.5–46.5) 43.4 (40.2–46.7) 47.7 (43.5–51.9) 41.9 (37.2–46.5) 0.78
Non-dense area in cm2
 Model 1a 66.8 (60.2–73.5) 65.1 (58.6–71.5) 66.2 (59.8–72.6) 74.8 (67.2–82.4) 92.4 (81.4–103.4) < 0.0001
 Model 2b 74.3 (69.6–79.0) 69.7 (64.8–74.6) 68.2 (63.2–73.2) 70.4 (65.1–75.7) 79.1 (71.4–86.8) 0.39
 Model 3c 74.2 (69.5–78.8) 69.7 (64.8–74.7) 68.3 (63.3–73.2) 69.9 (64.6–75.1) 79.8 (72.0–87.5) 0.35
Adolescent AHEI dietary pattern
  Q1 (least healthy) Q2 (unhealthy) Q3 (moderately healthy) Q4 (healthy) Q5 (most healthy) ptrendd
(n = 122) (n = 147) (n = 148) (n = 156) (n = 136)
Percent mammographic density
 Model 1a 42.2 (39.1–45.3) 41.6 (38.7–44.5) 40.2 (37.4–43.0) 40.5 (37.8–43.2) 40.7 (37.5–43.8) 0.44
 Model 2b 41.6 (39.0–44.3) 41.6 (39.2–44.1) 41.1 (38.7–43.5) 39.8 (37.3–42.3) 41.0 (38.4–43.6) 0.51
 Model 3c 41.0 (38.3–43.6) 41.7 (39.3–44.0) 41.0 (38.6–43.4) 40.2 (37.8–42.6) 41.4 (38.8–43.9) 0.89
Dense area in cm2
 Model 1a 42.9 (38.6–47.1) 45.7 (41.7–49.6) 43.1 (39.5–46.7) 43.4 (40.1–46.7) 44.7 (39.9–49.5) 0.83
 Model 2b 42.8 (38.6–47.1) 45.7 (41.7–49.6) 43.2 (39.5–46.8) 43.3 (40.1–46.6) 44.7 (39.9–49.5) 0.83
 Model 3c 42.1 (37.8–46.3) 45.8 (42.0–49.7) 43.4 (39.8–47.0) 43.5 (40.2–46.8) 44.8 (40.2–49.5) 0.66
Non-dense area in cm2
 Model 1a 65.8 (58.1–73.5) 74.5 (67.0–81.9) 70.8 (64.2–77.4) 72.5 (65.7–79.3) 74.5 (66.4–82.6) 0.25
 Model 2b 67.7 (62.6–72.9) 74.3 (69.1–79.5) 67.7 (62.8–72.6) 75.1 (69.5–80.6) 73.8 (68.6–79.1) 0.14
 Model 3c 68.6 (63.5–73.7) 74.3 (69.2–79.4) 68.1 (63.2–73.0) 74.4 (69.0–79.9) 73.5 (68.1–78.8) 0.27
  1. aAdjusted for adolescent total calorie intake and age at the time of mammogram
  2. bAdditionally adjusted for BMI at the time of mammogram
  3. cAdditionally adjusted for BMI at age 18 (kg/m2; cont.), adolescent physical activity (METs/week, quartiles), adolescent alcohol intake (drinker vs. non-drinkers), age at menarche (< 12; 12; 13; 14+ years), age at first birth (AFB) and parity combined (nulliparous; AFB < 25 years, 1–2 kids; AFB 25+ years, 1–2 kids; AFB any age, 3+ kids), history of biopsy-confirmed benign breast disease (yes; no), and first-degree family history of breast cancer (yes; no)
  4. dTrend test is based on the median of the category