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Table 2 Mean mammographic density phenotypes (95% confidence interval) by quintile of the adolescent dietary pattern (n = 709)

From: Adolescent and early adulthood inflammation-associated dietary patterns in relation to premenopausal mammographic density

Adolescent pro-inflammatory dietary pattern

 

Q1 (lowest inflammation)

Q2 (low inflammation)

Q3 (moderate inflammation)

Q4 (high inflammation)

Q5 (highest inflammation)

ptrendd

(n = 144)

(n = 159)

(n = 157)

(n = 142)

(n = 107)

Percent mammographic density

 Model 1a

41.7 (38.9–44.6)

42.8 (39.9–45.7)

42.8 (40.2–45.4)

40.9 (37.9–43.9)

34.8 (31.3–38.3)

0.005

 Model 2b

39.5 (37.2–41.8)

41.4 (38.9–44.0)

42.3 (40.0–44.6)

42.3 (39.8–44.9)

39.0 (35.9–42.0)

0.93

 Model 3c

39.6 (37.3–41.9)

41.3 (38.7–43.9)

42.0 (39.8–44.3)

42.9 (40.4–45.3)

38.7 (35.7–41.7)

0.93

Dense area in cm2

 Model 1a

43.6 (39.5–47.6)

43.5 (40.1–47.0)

43.8 (40.5–47.1)

46.8 (42.5–51.0)

41.6 (36.7–46.5)

0.97

 Model 2b

43.4 (39.3–47.5)

43.4 (40.0–46.9)

43.7 (40.4–47.0)

46.9 (42.6–51.1)

41.9 (37.2–46.7)

0.90

 Model 3c

43.5 (39.4–47.6)

43.0 (39.5–46.5)

43.4 (40.2–46.7)

47.7 (43.5–51.9)

41.9 (37.2–46.5)

0.78

Non-dense area in cm2

 Model 1a

66.8 (60.2–73.5)

65.1 (58.6–71.5)

66.2 (59.8–72.6)

74.8 (67.2–82.4)

92.4 (81.4–103.4)

< 0.0001

 Model 2b

74.3 (69.6–79.0)

69.7 (64.8–74.6)

68.2 (63.2–73.2)

70.4 (65.1–75.7)

79.1 (71.4–86.8)

0.39

 Model 3c

74.2 (69.5–78.8)

69.7 (64.8–74.7)

68.3 (63.3–73.2)

69.9 (64.6–75.1)

79.8 (72.0–87.5)

0.35

Adolescent AHEI dietary pattern

 

Q1 (least healthy)

Q2 (unhealthy)

Q3 (moderately healthy)

Q4 (healthy)

Q5 (most healthy)

ptrendd

(n = 122)

(n = 147)

(n = 148)

(n = 156)

(n = 136)

Percent mammographic density

 Model 1a

42.2 (39.1–45.3)

41.6 (38.7–44.5)

40.2 (37.4–43.0)

40.5 (37.8–43.2)

40.7 (37.5–43.8)

0.44

 Model 2b

41.6 (39.0–44.3)

41.6 (39.2–44.1)

41.1 (38.7–43.5)

39.8 (37.3–42.3)

41.0 (38.4–43.6)

0.51

 Model 3c

41.0 (38.3–43.6)

41.7 (39.3–44.0)

41.0 (38.6–43.4)

40.2 (37.8–42.6)

41.4 (38.8–43.9)

0.89

Dense area in cm2

 Model 1a

42.9 (38.6–47.1)

45.7 (41.7–49.6)

43.1 (39.5–46.7)

43.4 (40.1–46.7)

44.7 (39.9–49.5)

0.83

 Model 2b

42.8 (38.6–47.1)

45.7 (41.7–49.6)

43.2 (39.5–46.8)

43.3 (40.1–46.6)

44.7 (39.9–49.5)

0.83

 Model 3c

42.1 (37.8–46.3)

45.8 (42.0–49.7)

43.4 (39.8–47.0)

43.5 (40.2–46.8)

44.8 (40.2–49.5)

0.66

Non-dense area in cm2

 Model 1a

65.8 (58.1–73.5)

74.5 (67.0–81.9)

70.8 (64.2–77.4)

72.5 (65.7–79.3)

74.5 (66.4–82.6)

0.25

 Model 2b

67.7 (62.6–72.9)

74.3 (69.1–79.5)

67.7 (62.8–72.6)

75.1 (69.5–80.6)

73.8 (68.6–79.1)

0.14

 Model 3c

68.6 (63.5–73.7)

74.3 (69.2–79.4)

68.1 (63.2–73.0)

74.4 (69.0–79.9)

73.5 (68.1–78.8)

0.27

  1. aAdjusted for adolescent total calorie intake and age at the time of mammogram
  2. bAdditionally adjusted for BMI at the time of mammogram
  3. cAdditionally adjusted for BMI at age 18 (kg/m2; cont.), adolescent physical activity (METs/week, quartiles), adolescent alcohol intake (drinker vs. non-drinkers), age at menarche (< 12; 12; 13; 14+ years), age at first birth (AFB) and parity combined (nulliparous; AFB < 25 years, 1–2 kids; AFB 25+ years, 1–2 kids; AFB any age, 3+ kids), history of biopsy-confirmed benign breast disease (yes; no), and first-degree family history of breast cancer (yes; no)
  4. dTrend test is based on the median of the category
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Breast Cancer Research

ISSN: 1465-542X

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