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Fig. 1 | Breast Cancer Research

Fig. 1

From: Single cell transcriptome atlas of mouse mammary epithelial cells across development

Fig. 1

Heterogeneity among E18.5 mammary epithelium and adjacent skin cells. a Schematic diagram showing key developmental stages for the mouse mammary gland. b t-SNE plots showing the combined single cell transcriptomes of mammary epithelial cells and adjacent skin cells isolated from E18.5 embryos (n = 7 female embryos). Cell clusters identified by Seurat’s Louvain algorithm with resolution 0.03. c Same t-SNE plot as in b but colored by cell type: mammary epithelial cells (blue) and adjacent skin cells (yellow). d Same t-SNE plot as b and c but colored by relative expression (gray = low, red = high) of epithelial (Epcam), basal (Krt14, Krt5), and luminal (Ecad, Aldh1a3, and Gata3) genes. e Heat map showing relative log-expression of the top 30 marker genes for each cell cluster identified in Fig. 1b. f KEGG pathway analysis of genes differentially expressed between clusters shown in b

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