Fig. 6
From: Accelerated aging in normal breast tissue of women with breast cancer
Outlier analysis of TCGA normal adjacent and breast cancer samples. a A Lasso regression model was built on the DNA methylation values of 146 aging sites in all non-outlier samples from the six DNA methylation datasets (blue) to predict the ages of all other samples: the outlier samples in normal adjacent (red), the not-outlier cancer samples (gray), and the outlier cancer samples (orange). The chronological ages (x-axis) and the predicted ages (y-axis) are shown in the scatter plot. b Comparison of the absolute difference between the predicted ages and the chronological ages (y-axis) in outliers and not-outliers in normal adjacent (red, blue) and in cancer (orange, gray). Significance was tested by the Kruskal-Wallis test followed by a post hoc Dunn test with multiple testing correction using the Benjamini-Hochberg method