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Table 3 Distribution of clinical parameters according to the ERα/PI3K expression

From: Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant

Variable

ERα/PI3K ≤9, no. (%)

ERα/PI3K >9, no. (%)

P

Age groups

<50 years

75 (28.7)

36 (23.1)

0.206

>50 years

186 (71.3)

120 (76.9)

T. size

<2 cm

157 (60.2)

84 (53.8)

0.207

>2 cm

104 (39.8)

72 (46.2)

LN invasion

No

115 (44.1)

60 (38.5)

0.262

Yes

146 (55.9)

96 (61.5)

SBR grade

Gr 1

54 (20.7)

25 (16.0)

0.069

Gr 2

130 (49.8)

68 (43.6)

Gr 3

77 (29.5)

63 (40.4)

ER status

Negative

31 (11.9)

22 (14.1)

0.509

Positive

230 (88.1)

134 (85.9)

PR status

Negative

60 (23.0)

45 (28.8)

0.182

Positive

201 (77.0)

111 (71.2)

HER2 status

Negative

238 (93.0)

144 (92.3)

0.802

Positive

18 (7.0)

12 (7.7)

Breast Cancer subtype

Luminal A

155 (59.4)

77 (49.4)

0.249

Luminal B

75 (28.7)

57 (36.5)

HER2 rich

6 (2.3)

5 (3.2)

TNBC

25 (9.6)

17 (10.9)

Type of adjuvant hormonal

Tamoxifen

97 (57.1)

65 (49.2)

0.151

AI

129 (42.9)

67 (50.8)