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Fig. 5 | Breast Cancer Research

Fig. 5

From: Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer

Fig. 5

Histological analysis of lungs and livers in the Y537S ERα mutant model. a Representative IHC staining of lungs with anti-luciferase antibody showing lung metastases (brown). b Quantitation of the IHC staining showing metastasis as percent of total lung area (n = 5–6 mice). c Representative H&E staining of livers. d Quantitation of the H&E staining showing the area of tumor cells normalized to the total liver area (n = 5–6 mice). Error bars represent standard error of the mean. F, fulvestrant; L5 and L10, lasofoxifene at 5 and 10 mg/kg; P35 and P70, palbociclib at 35 and 70 mg/kg; V, vehicle. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 by one-way ANOVA

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