Skip to main content
Fig. 4 | Breast Cancer Research

Fig. 4

From: Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer

Fig. 4

Effect of combination therapies on tumor metastasis in the Y537S ERα mutant model. Ex vivo radiance of luciferase activity was measured in excised a long bones (n = 10–12 legs), b brains (n = 5–6 mice), c lungs (n = 5–6 mice), and d livers (n = 5–6 mice). Error bars represent standard error of the mean. F, fulvestrant; L5 and L10, lasofoxifene at 5 and 10 mg/kg; P35 and P70, palbociclib at 35 and 70 mg/kg; V, vehicle. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 by one-way ANOVA

Back to article page