Fig. 4From: Functional consequences of a rare missense BARD1 c.403G>A germline mutation identified in a triple-negative breast cancer patientBARD1 p.Asp127Asn increased sensitivity of mice to irradiation. a Point mutation D127N-#5, b point mutation D127N-#8, c four amino acid deletion, and d six amino acid deletion were exposed to a sub-lethal dose (7 Gy) of total body irradiation (TBI). The littermate wild-type mice were used as controls. Survival at day 20 after TBI was analyzed and shown as percent mortality on the Y-axis. Survival curves of wild-type (WT) and homozygous mutation (Hom) mice after sub-lethal irradiation were shown. n ≥ 7 mice per genotype. P values shown are for the Wald testBack to article page