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Table 1 Characteristics of the women

From: Association between menopausal hormone therapy, mammographic density and breast cancer risk: results from the E3N cohort study

Characteristic

All (N = 906)

Controls (N = 453)

Cases (N = 453)

Reference age (years)*

61 (59 to 66)

61 (59 to 66)

61 (59 to 66)

Age at mammogram (years)*

61 (58 to 65)

61 (58 to 65)

60 (58 to 65)

MHT at mammogram, N (%)

 Never

189 (20.9)

110 (24.3)

79 (17.4)

 Current

432 (47.7)

217 (47.9)

215 (47.5)

 Past, 0–2 years since last use

154 (17.0)

50 (11.0)

104 (23.0)

 Past, > 2 years since last use

131 (14.5)

76 (16.8)

55 (12.1)

Type of MHT at mammogram, N (%)

 None

189 (20.9)

110 (24.3)

79 (17.4)

 Oestrogen

30 (3.3)

15 (3.3)

15 (3.3)

 Oestrogens plus progestogens

490 (54.1)

233 (51.4)

257 (56.7)

  Oestrogen plus progesterone or dydrogesterone

138 (15.2)

79 (17.4)

59 (13.0)

  Oestrogen plus progestins

239 (26.4)

99 (21.9)

140 (30.9)

  Both

113 (12.5)

55 (12.1)

58 (12.8)

 Others

197 (21.7)

95 (21.0)

102 (22.5)

BMI at mammogram (kg/m2)*

22.9 (21.1 to 25.1)

22.8 (21.0 to 24.8)

23.1 (21.3 to 25.4)

PMD*

32 (20 to 45)

31 (17 to 43)

35 (23 to 49)

DA (cm2)*

33 (20 to 47)

29 (17 to 42)

35 (23 to 52)

NDA (cm2)*

70 (47 to 97)

72 (49 to 97)

68 (46 to 96)

ER and PR status, N (%)**

 ER+ and PR+

  

224 (60.6)

 ER+ and PR−

  

77 (20.8)

 ER− and PR+

  

13 (3.5)

 ER− and PR−

  

56 (15.1)

Family history of breast cancer in first-degree relatives, N (%)

 No

771 (85.1)

394 (87.0)

377 (83.2)

 Yes

135 (14.9)

59 (13.0)

76 (16.8)

Age of menarche (years), N (%)

 < 12

162 (17.9)

69 (15.2)

93 (20.5)

 12

244 (26.9)

125 (27.6)

119 (26.3)

 > 12

500 (55.2)

259 (57.2)

241 (53.2)

Past use of oral contraceptives, N (%)

 No

452 (49.9)

232 (51.2)

220 (48.6)

 Yes

454 (50.1)

221 (48.8)

233 (51.4)

Parity and lactation, N (%)**

 Nulliparous

116 (13.6)

59 (14.0)

57 (13.3)

 Parous without lactation

205 (24.1)

94 (22.3)

111 (25.8)

 Parous with lactation for less than 4 months

246 (28.9)

123 (29.2)

123 (28.6)

 Parous with lactation for 4 months or more

284 (33.4)

145 (34.4)

139 (32.3)

  1. For each matched case-control pair, reference age is the age at diagnosis of the case
  2. MHT menopausal hormone therapy, BMI body mass index, PMD percent mammographic density, DA dense area, NDA non-dense area, ER oestrogen receptor, PR progesterone receptor
  3. *Median (interquartile range)
  4. **Number of missing: ER/PR status, 83; Parity and lactation, 55