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Fig. 6 | Breast Cancer Research

Fig. 6

From: Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy

Fig. 6

Schematic illustrating mechanisms of biglycan modulating tumor microenvironment. Inactivation of tumor stromal biglycan normalizes tumor vasculature via downregulation of Angpt2. Biglycan knockout in tumor stroma decreases tumor stiffness and increases the accumulation of CD8+ T cells. Thus, targeting stromal biglycan can facilitate drug delivery in tumors

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