Table 3 Univariate and multivariate Cox regression analyses of DFS including various prognostic parameters in patients with BC

Age(<50 years vs. ≥ 50 years)

0.19

0.732

0.459–1.167

0.134

0.537

0.238–1.210

Molecular subtype (LuA-like vs. LuB-like vs. TNBC vs. HER2 Lu-like vs. HER2 nonLu like)

0.329

1.093

0.914–1.307

n.i.

n.i.

n.i.

Grading (G1 vs. G2 vs. G3)

0.03*

1.669

1.050–2.654

0.043*

1.825

1.018–3.271

Tumor foci (unifocal vs. multifocal and multicentric)

0.370

1.214

0.794–1.857

n.i.

n.i.

n.i.

Tumor size (pT1 vs. pT2 vs. pT3 vs. pT4)

0.002*

1.493

1.159–1.922

0.011*

1.646

1.120–2.418

Axillary lymph node status (pN0 vs. pN1 vs.pN2)

0.01*

1.696

1.137–2.528

0.856

1.078

0.482–2.411

ER status (ER− vs. ER+)

0.771

0.926

0.550–1.557

n.i.

n.i.

n.i.

PR status (PR− vs. PR+)

0.249

1.291

0.836–1.994

n.i.

n.i.

n.i.

HER2 status (HER2− vs. HER2+)

0.511

1.228

0.666–2.262

n.i.

n.i.

n.i.

Expression of ki-67 (ki-67 ≤ 14% vs. ki-67>14%)

0.093

1.569

0.928–2.653

n.i.

n.i.

n.i.

BATMs (low vs. high)

0.035*

1.800

1.042–3.108

0.005*

3.240

1.423–7.378

BTSMs (low vs. high)

0.432

1.285

0.687–2.403

n.i.

n.i.

n.i.