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Table 3 Univariate and multivariate Cox regression analyses of DFS including various prognostic parameters in patients with BC

From: Breast adipose tissue macrophages (BATMs) have a stronger correlation with breast cancer survival than breast tumor stroma macrophages (BTSMs)

  Univariate analysis Multivariate analysis
p HR 95% CI p HR 95% CI
Age(<50 years vs. ≥ 50 years) 0.19 0.732 0.459–1.167 0.134 0.537 0.238–1.210
Molecular subtype (LuA-like vs. LuB-like vs. TNBC vs. HER2 Lu-like vs. HER2 nonLu like) 0.329 1.093 0.914–1.307 n.i. n.i. n.i.
Grading (G1 vs. G2 vs. G3) 0.03* 1.669 1.050–2.654 0.043* 1.825 1.018–3.271
Tumor foci (unifocal vs. multifocal and multicentric) 0.370 1.214 0.794–1.857 n.i. n.i. n.i.
Tumor size (pT1 vs. pT2 vs. pT3 vs. pT4) 0.002* 1.493 1.159–1.922 0.011* 1.646 1.120–2.418
Axillary lymph node status (pN0 vs. pN1 vs.pN2) 0.01* 1.696 1.137–2.528 0.856 1.078 0.482–2.411
ER status (ER− vs. ER+) 0.771 0.926 0.550–1.557 n.i. n.i. n.i.
PR status (PR− vs. PR+) 0.249 1.291 0.836–1.994 n.i. n.i. n.i.
HER2 status (HER2− vs. HER2+) 0.511 1.228 0.666–2.262 n.i. n.i. n.i.
Expression of ki-67 (ki-67 ≤ 14% vs. ki-67>14%) 0.093 1.569 0.928–2.653 n.i. n.i. n.i.
BATMs (low vs. high) 0.035* 1.800 1.042–3.108 0.005* 3.240 1.423–7.378
BTSMs (low vs. high) 0.432 1.285 0.687–2.403 n.i. n.i. n.i.
  1. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2, LuA-like luminal A-like, LuB-like luminal B-like, TNBC triple-negative breast cancer, HER2 Lu-like HER2 amplified luminal-like, HER2 nonLu like HER2 amplified non luminal-like, BTAMs breast adipose tissue macrophages, BTSMs breast tumor-stroma macrophages, HR hazard ratio, CI confidence interval, n.i not included in multivariate model, as p > 0.05 in univariate analysis, *significant (p value < 0.05)