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Table 2 Univariate and multivariate Cox regression analyses of OS including various prognostic parameters in patients with BC

From: Breast adipose tissue macrophages (BATMs) have a stronger correlation with breast cancer survival than breast tumor stroma macrophages (BTSMs)

  Univariate analysis Multivariate analysis model 3 (with both BATM and BTSM)
p HR 95% CI p HR 95% CI
Age (<50 years vs. ≥ 50 years) 0.055 1.746 0.987–3.088 0.741 0.843 0.305–2.326
Molecular subtype (LuA-like vs. LuB-like vs. TNBC vs. HER2 Lu-like vs. HER2 nonLu like) 0.03* 1.213 1.018–1.444 0.185 1.351 0.866–2.107
Grading (G1 vs. G2 vs. G3) 0.003* 1.763 1.056–2.945 0.405 1.403 0.633–3.110
Tumor foci (unifocal vs. multifocal and multicentric) 0.889 0.971 0.642–1.469 n.i. n.i. n.i.
Tumor size (pT1 vs. pT2 vs. pT3 vs. pT4) 5.573E−13* 2.064 1.695–2.513 0.001* 1.827 1.269–2.631
Axillary lymph node status (pN0 vs. pN1 vs.pN2) 0.002* 1.859 1.256–2.749 0.285 1.650 0.659–4.131
ER status (ER− vs. ER+) 0.026* 0.589 0.369–0.940 0.604 0.718 0.205–2.515
PR status (PR− vs. PR+) 0.088 0.697 0.461–1.054 n.i. n.i. n.i.
HER2 status (HER2− vs. HER2+) 0.079 1.667 0.942–2.952 n.i. n.i. n.i.
Expression of ki-67 (ki-67 ≤ 14% vs. ki-67>14%) 0.891 1.040 0.588–1.840 n.i. n.i. n.i.
BATMs (low vs. high) 0.001* 2.483 1.474–4.182 0.004* 4.464 1.624–12.269
BTSMs (low vs. high) 0.025* 2.445 1.117–5.354 0.737 0.813 0.243–2.721
  1. Multivariate analysis model 3 was performed with both BATMs and BTSMs, to determine if BATMs, BTSM or both were independently associated with OS when both subtypes of macrophages were considered. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2, LuA-like luminal A-like, LuB-like luminal B-like, TNBC triple-negative breast cancer, HER2 Lu-like HER2 amplified luminal-like, HER2 nonLu like HER2 amplified non luminal-like, BATMs breast adipose tissue macrophages, BTSMs breast tumor-stroma macrophages, HR hazard ratio, CI confidence interval, n.i not included in multivariate model as p > 0.05 in univariate analysis; *significant (p value < 0.05)