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Table 1 Distribution of BATMs and BTSMs compared to clinical and pathological parameters in our BC cohort

From: Breast adipose tissue macrophages (BATMs) have a stronger correlation with breast cancer survival than breast tumor stroma macrophages (BTSMs)

Parameters Total BATM-low BATM-high BTSM-low BTSM-high
Number of cases (%) Number of cases (%) Number of cases (%) Number of cases (%) Number of cases (%)
Age
 ≥ 50 years 226 (75.8) 123 (75.0) 41 (25.0) 31 (17.2) 149 (82.3)
 <50 years 72 (24.2) 47 (83.9) 9 (16.1) 11 (16.7) 51 (77.3)
 Chi-square p value   0.169 0.926
Molecular subtype
 Luminal A-like 166 (55.7) 99 (78.0) 28 (22.0) 37 (26.8) 101 (73.2)
 Luminal B-like 60 (20.1) 39 (79.6) 10 (20.4) 2 (3.8) 50 (96.2)
 Triple negative 38 (12.8) 16 (66.7) 8 (33.3) 0 (0.0) 30 (100.0)
 HER2 amplified luminal-like 24 (8.1) 11 (78.6) 3 (21.4) 1 (6.3) 15 (93.7)
 HER2 amplified non luminal-like 8 (2.7) 5 (83.3) 1 (16.7) 2 (33.3) 4 (66.7)
 Chi square p value   0.779 0.000011***
Grading
 G1 15 (5) 7 (63.6) 4 (36.4) 4 (30.8) 9 (69.2)
 G2 103 (34.6) 56 (77.8) 16 (22.2) 12 (15.0) 68 (85.0)
 G3 44 (14.8) 25 (78.1) 7 (21.9) 7 (20.6) 27 (79.4)
 Chi-square p value   0.594 0.337
Tumor foci
 Unifocal 161 (54.0) 87 (74.4) 30 (25.6) 21 (16.0) 110 (84.0)
 Multifocal/multicentric 137 (46.0) 83 (80.6) 20 (19.4) 21 (18.9) 90 (81.1)
 Chi-square p value   0.272 0.554
Tumor size
 pT1 194 (65.1) 114 (80.3) 28 (19.7) 31 (20.0) 124 (80.0)
 pT2 87 (29.2) 49 (75.4) 16 (24.6) 8 (11.1) 64 (88.9)
 pT3 4 (1.3) 1 (33.3) 2 (66.7) 0 (0.0) 3 (100.0)
 pT4 13 (4.4) 6 (60.0) 4 (40.0) 3 (25.0) 9 (75.0)
 Chi-square p value   0.094 0.276
Axillary lymph node status
 pN0 164 (55.0) 91 (77.8) 26 (22.2) 23 (17.6) 108 (82.4)
 pN1 124 (41.6) 73 (76.8) 22 (23.2) 18 (17.6) 84 (82.4)
 pN2 4 (1.3) 1 (33.3) 2 (66.7) 0 (0.0) 4 (100.0)
 Chi-square p value   0.224 0.796
ER status
 Negative 57 (19.1) 28 (75.7) 9 (24.3) 4 (8.9) 41 (91.1)
 Positive 241 (80.9) 142 (77.6) 41 (22.4) 38 (19.3) 159 (80.7)
 Chi-square p value   0.799 0.096
PR status
 Negative 128 (43.0) 67 (75.3) 22 (24.7) 20 (25.0) 80 (75.0)
 Positive 170 (57.0) 103 (78.6) 28 (21.4) 22 (15.5) 120 (84.5)
 Chi-square p value   0.561 0.362
HER2 status
 Negative 263 (88.3) 154 (77.4) 45 (22.6) 39 (17.8) 180 (82.2)
 Positive 33 (11.1) 16 (76.2) 5 (23.8) 3 (13.0) 20 (87.0)
 Chi-square p value   1.000 0.774
Expression of Ki-67
 ≤ 14% 167 (56.0) 100 (78.1) 28 (21.9) 37(26.6) 102 (73.4)
 >14% 60 (20.1) 39 (79.6) 10 (20.4) 2(3.8) 50 (96.2)
 Chi-square p value   0.832 0.001**
Expression of EP3
 Low (IRS ≤ 1) 87 (29.2) 43 (68.3) 20 (31.7) 16 (22.2) 56 (77.8)
 High (IRS >1) 201 (67.4) 124 (80.5) 30 (19.5) 26 (15.5) 142 (84.5)
 Chi-square p value   0.051 0.208