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Table 4 Associations of risk of hormone receptor-positive (HR+) and HR-negative (HR−) invasive breast cancers with summary phthalate exposures in all women combined

From: Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study

Summary phthalate All women
HR+ n = 694 HR− n = 96
OR (95% CI)a Cases/controls OR (95% CI)a Cases/controls
∑DEHP
 < 118.53 1.00 443/508 1.00 58/508
 ≥ 118.53 1.02 (0.82–1.26) 251/288 1.05 (0.67–1.64) 38/288
P value 0.87   0.83  
P hetb 0.90    
∑HMWP
 < 106.79 1.00 369/405 1.00 45/405
 ≥ 106.79 0.93 (0.76–1.15) 325/391 1.15 (0.75–1.78) 51/391
P value 0.50   0.52  
P hetb 0.39    
∑LMWP
 < 93.03 1.00 317/408 1.00 40/408
 ≥ 93.03 1.30 (1.05–1.60) 377/388 1.28 (0.81–2.00) 56/388
P value 0.015   0.29  
P hetb 0.95    
∑LMHMPA
 < 310.52 1.00 332/408 1.00 38/408
 ≥ 310.52 1.17 (0.95–1.44) 362/388 1.54 (0.98–2.41) 58/388
P value 0.15   0.06  
P hetb 0.28    
∑LMHMmolar
 < 0.80 1.00 331/411 1.00 40/411
 ≥ 0.80 1.20 (0.98–1.48) 363/385 1.40 (0.90–2.19) 56/385
P value 0.08   0.14  
P hetb 0.55    
Phthalic acid
 < 53.54 1.00 343/399 1.00 36/399
 ≥ 53.54 1.02 (0.83–1.26) 351/397 1.59 (1.01–2.48) 60/397
P value 0.84   0.04  
P hetb 0.08    
  1. aUnconditional logistic regression adjusting for matching factors including area, age, time of urine collection, type of urine specimen, education, number of children, age at menarche, menopausal status, BMI at urine collection, neighborhood socioeconomic status at urine collection, smoking, alcohol intake, and Mediterranean energy adjusted total score. Both HR+ and HR− were compared to 796 control women in all women combined analyses
  2. bP heterogeneity (HR+ vs HR−) df = 1