From: Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study
Metabolites (ng/g creatinine) | All (1032 ca/1030 co) | Whites (274 ca/273 co) | Japanese Americans (478ca/478co) | Native Hawaiians (155 ca/154 co) | African Americans and Latinos (125 ca/125 co) | Phet raceb |
---|---|---|---|---|---|---|
OR (95% CI)a | OR (95% CI)a | OR (95% CI)a | OR (95% CI)a | OR (95% CI)a | ||
MMP | ||||||
≤ 2.63 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 2.63–7.40 | 0.82 (0.65–1.04) | 0.71 (0.44–1.13) | 0.86 (0.61–1.23) | 1.16 (0.68–1.99) | 0.54 (0.26–1.10) | |
> 7.40 | 0.89 (0.69–1.15) | 0.89 (0.53–1.49) | 0.84 (0.57–1.24) | 1.22 (0.62–2.37) | 0.74 (0.36–1.50) | |
P trendc | 0.26 | 0.49 | 0.36 | 0.52 | 0.30 | 0.59 |
MEP | ||||||
≤ 30.64 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 30.64–84.30 | 1.08 (0.86–1.35) | 0.93 (0.60–1.42) | 1.06 (0.78–1.45) | 1.63 (0.92–2.90) | 0.82 (0.33–2.03) | |
> 84.30 | 1.07 (0.84–1.35) | 1.13 (0.72–1.78) | 0.97 (0.69–1.38) | 1.50 (0.85–2.66) | 0.75 (0.32–1.80) | |
P trendc | 0.56 | 0.67 | 0.95 | 0.12 | 0.52 | 0.63 |
MBP | ||||||
≤ 12.92 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 12.92–24.60 | 0.83 (0.66–1.04) | 0.99 (0.62–1.58) | 0.84 (0.61–1.15) | 0.89 (0.51–1.55) | 0.53 (0.24–1.16) | |
> 24.60 | 0.87 (0.69–1.11) | 0.82 (0.52–1.29) | 1.04 (0.73–1.48) | 0.64 (0.34–1.20) | 0.70 (0.35–1.40) | |
P trendc | 0.21 | 0.41 | 0.93 | 0.20 | 0.41 | 0.80 |
MiBP | ||||||
≤ 3.12 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 3.12–6.64 | 0.95 (0.75–1.21) | 0.73 (0.44–1.19) | 0.86 (0.60–1.22) | 1.39 (0.77–2.49) | 1.52 (0.68–3.42) | |
> 6.64 | 1.15 (0.89–1.49) | 0.74 (0.45–1.23) | 1.21 (0.82–1.79) | 2.07 (1.02–4.21) | 1.33 (0.64–2.75) | |
P trendc | 0.36 | 0.23 | 0.83 | 0.05 | 0.52 | 0.16 |
MBzP | ||||||
≤ 7.66 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 7.66–15.83 | 0.81 (0.65–1.01) | 0.69 (0.45–1.06) | 0.87 (0.63–1.21) | 0.67 (0.37–1.21) | 1.05 (0.56–1.97) | |
> 15.83 | 0.79 (0.63–0.99) | 0.67 (0.43–1.03) | 0.86 (0.61–1.20) | 0.86 (0.47–1.57) | 0.77 (0.41–1.46) | |
P trendc | 0.03 | 0.05 | 0.35 | 0.53 | 0.52 | 0.56 |
MEHP | ||||||
≤ 4.72 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 4.72–10.88 | 1.00 (0.79–1.26) | 0.91 (0.57–1.43) | 0.86 (0.61–1.22) | 1.74 (0.94–3.22) | 1.23 (0.61–2.44) | |
> 10.88 | 1.01 (0.77–1.31) | 1.06 (0.46–1.63) | 0.76 (0.52–1.12) | 2.73 (1.25–5.97) | 1.08 (0.52–2.27) | |
P trendc | 0.97 | 0.94 | 0.17 | 0.01 | 0.81 | 0.07 |
MEHHP | ||||||
≤ 18.44 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 18.44–39.67 | 0.96 (0.77–1.20) | 0.73 (0.47–1.14) | 0.98 (0.71–1.34) | 1.37 (0.79–2.35) | 1.03 (0.53–2.02) | |
> 39.67 | 0.93 (0.74–1.18) | 0.69 (0.44–1.11) | 0.97 (0.69–1.35) | 1.67 (0.90–3.08) | 0.80 (0.39–1.61) | |
P trendc | 0.56 | 0.11 | 0.83 | 0.09 | 0.56 | 0.23 |
MEOHP | ||||||
≤ 11.54 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 11.54–26.28 | 1.03 (0.83–1.28) | 0.66 (0.43–1.02) | 1.21 (0.88–1.67) | 1.21 (0.71–2.05) | 1.09 (0.57–2.12) | |
> 26.28 | 0.90 (0.72–1.13) | 0.66 (0.42–1.05) | 1.03 (0.74–1.44) | 1.27 (0.71–2.24) | 0.65 (0.33–1.29) | |
P trendc | 0.46 | 0.06 | 0.67 | 0.39 | 0.28 | 0.24 |
MECPP | ||||||
≤ 23.04 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 23.04–45.35 | 0.94 (0.75–1.18) | 0.81 (0.52–1.26) | 0.91 (0.65–1.26) | 1.22 (0.68–2.19) | 1.10 (0.57–2.14) | |
> 45.35 | 0.99 (0.78–1.25) | 0.77 (0.49–1.22) | 0.98 (0.70–1.38) | 1.94 (1.01–3.70) | 0.80 (0.38–1.66) | |
P trendc | 0.84 | 0.25 | 0.84 | 0.06 | 0.62 | 0.27 |
MCHP | ||||||
≤ 0.34 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 0.34–0.57 | 1.11 (0.88–1.39) | 1.10 (0.71–1.70) | 1.19 (0.85–1.67) | 1.28 (0.73–2.25) | 0.72 (0.36–1.44) | |
> 0.57 | 1.16 (0.91–1.47) | 1.25 (0.77–2.03) | 1.08 (0.75–1.54) | 1.78 (0.91–3.47) | 0.86 (0.45–1.64) | |
P trendc | 0.23 | 0.39 | 0.58 | 0.10 | 0.49 | 0.51 |
MEHP%d | ||||||
≤ 5.49% | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 5.49–11.08% | 1.27 (1.00–1.61) | 1.46 (0.93–2.30) | 1.09 (0.77–1.56) | 1.63 (0.88–3.03) | 1.22 (0.62–2.38) | |
> 11.08% | 1.23 (0.94–1.62) | 1.81 (1.06–3.08) | 0.97 (0.65–1.46) | 1.46 (0.73–2.92) | 1.03 (0.46–2.28) | |
P trendc | 0.09 | 0.03 | 0.94 | 0.22 | 0.84 | 0.44 |
MEHP/(MEOHP + MEHHP) | ||||||
≤ 9.76% | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 9.76–21.36% | 1.32 (1.04–1.68) | 1.57 (1.00–2.44) | 1.18 (0.82–1.71) | 1.46 (0.79–2.70) | 1.21 (0.62–2.38) | |
> 21.36% | 1.26 (0.96–1.66) | 2.10 (1.20–3.65) | 0.98 (0.66–1.47) | 1.14 (0.56–2.34) | 1.38 (0.63–3.03) | |
P trendc | 0.05 | 0.007 | 0.97 | 0.55 | 0.42 | 0.30 |
MEHP/(MECCP + MEHHP) | ||||||
≤ 7.87% | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 7.87–16.86% | 1.28 (1.02–1.63) | 1.35 (0.86–2.08) | 1.20 (0.85–1.77) | 1.38 (0.76–2.49) | 1.36 (0.68–2.70) | |
> 16.86% | 1.18 (0.90–1.56) | 1.76 (1.04–2.99) | 1.01 (0.67–1.53) | 1.14 (0.58–2.24) | 0.92 (0.41–2.05) | |
P trendc | 0.13 | 0.04 | 0.82 | 0.56 | 0.93 | 0.64 |
MEHP/MEHHP | ||||||
≤ 0.159 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 0.159–0.341 | 1.20 (0.94–1.54) | 1.31 (0.84–2.04) | 1.07 (0.73–1.57) | 1.31 (0.69–2.49) | 1.28 (0.64–2.56) | |
> 0.341 | 1.24 (0.94–1.63) | 1.84 (1.05–3.21) | 1.08 (0.72–1.63) | 0.90 (0.44–1.84) | 1.31 (0.59–2.94) | |
P trendc | 0.11 | 0.04 | 0.70 | 0.92 | 0.45 | 0.60 |
MEHP/MEOHP | ||||||
≤ 0.245 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 0.245–0.548 | 1.36 (1.08–1.71) | 1.92 (1.23–2.99) | 1.09 (0.78–1.53) | 1.32 (0.73–2.41) | 1.48 (0.75–2.93) | |
> 0.548 | 1.26 (0.97–1.63) | 2.02 (1.17–3.50) | 0.92 (0.63–1.35) | 1.29 (0.69–2.42) | 1.62 (0.75–3.50) | |
P trendc | 0.04 | 0.004 | 0.79 | 0.38 | 0.20 | 0.14 |
MEHP/MECPP | ||||||
≤ 0.137 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 0.137–0.298 | 1.17 (0.93–1.48) | 1.11 (0.72–1.72) | 1.11 (0.78–1.59) | 1.36 (0.75–2.47) | 1.25 (0.63–2.48) | |
> 0.298 | 0.96 (0.73–1.25) | 1.14 (0.69–1.88) | 0.80 (0.53–1.21) | 1.12 (0.57–2.34) | 0.97 (0.43–2.20) | |
P trendc | 0.99 | 0.59 | 0.78 | 0.57 | 0.52 | 0.78 |
Phthalic acid (PA) | ||||||
≤ 36.90 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |
> 36.90–79.76 | 1.11 (0.88–1.40) | 0.95 (0.60–1.52) | 1.19 (0.86–1.64) | 1.61 (0.81–3.21) | 0.81 (0.39–1.69) | |
> 79.76 | 1.21 (0.94–1.56) | 0.98 (0.61–1.58) | 1.17 (0.80–1.69) | 2.22 (1.08–4.57) | 1.04 (0.47–2.30) | |
P trendc | 0.14 | 0.94 | 0.32 | 0.03 | 0.92 | 0.39 |