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Fig. 8 | Breast Cancer Research

Fig. 8

From: Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice

Fig. 8

Relationship between latent TFGB1 and the abundance of CD68-positive macrophages in human breast tissue. Representative latent TGFB1 (a, b) and CD68 (c, d) antibody staining of human non-neoplastic breast tissue. Examples are of high (a) and low (b) staining intensity for latent TGFB1 and the same patient sample stained with CD68 antibody (c and d, respectively). Epithelial-associated CD68-positive macrophages were located between adjacent epithelial cells (arrows), epithelial-aligned CD68-positive macrophages were macrophages that aligned along the epithelium but not invaded into the epithelium (dashed arrows), and stromal CD68-positive macrophages were macrophages within the stroma (arrowheads). The intensity of latent TGFB1 staining and abundance of CD68-positive macrophages in breast tissue was analysed by linear regression (n = 19); latent TGFB1 vs. CD68-positive macrophages in the stroma, p < 0.05 (e); latent TGFB1 vs. CD68-positive macrophages associated with epithelium, p < 0.05 (f)

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